Evidence map›Paper›PMID 26045345›Full record

ArticleEuropean radiology2016

Comparison of cone-beam CT-guided and CT fluoroscopy-guided transthoracic needle biopsy of lung nodules.

Nicola Rotolo, Chiara Floridi, Andrea Imperatori, Federico Fontana, Anna Maria Ierardi, Monica Mangini, Veronica Arlant, Giuseppe De Marchi, Raffaele Novario, Lorenzo Dominioni and 2 more

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06762613 (Enhancing CBCT-Guided Lung Nodule Puncture Efficiency With Generative AI), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06762613 nacompletednot on this mapstarted 2025, after this paper: background citation

Enhancing CBCT-Guided Lung Nodule Puncture Efficiency With Generative AI

TypeinterventionalSponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRan2025 to 2025Enrolled220ConditionsLung NodulesArmsGenerative AI Based Puncture Surgery Navigation System, Cone beam CT
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  10. Computed tomography-guided transforaminal lumbar puncture using local anesthesia and a straight 22-gauge spinal needle for intrathecal nusinersen in adults: Findings in 77 procedures.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Article
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  13. Computed tomography-guided core needle biopsy for lung nodules: low-dose versus standard-dose protocols.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2021
    Article
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  16. Cone-Beam CT-Guided Lung Biopsies: Results in 94 Patients.Diagnostics (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Nicola RotoloCenter for Thoracic Surgery, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Chiara FloridiRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Andrea ImperatoriCenter for Thoracic Surgery, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Federico FontanaRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Anna Maria IerardiRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Monica ManginiRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Veronica ArlantCenter for Thoracic Surgery, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Giuseppe De MarchiRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Raffaele NovarioMedical Physics Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Lorenzo DominioniCenter for Thoracic Surgery, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Carlo FugazzolaRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy.
Gianpaolo CarrafielloRadiology Department, Insubria University, Viale Borri 57, 21100, Varese, Italy. gcarraf@gmail.com.
University of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the diagnostic performance of cone-beam CT (CBCT)-guided and CT fluoroscopy (fluoro-CT)-guided technique for transthoracic needle biopsy (TNB) of lung nodules.

methodsThe hospital records of 319 consecutive patients undergoing 324 TNBs of lung nodules in a single radiology unit in 2009-2013 were retrospectively evaluated. The newly introduced CBCT technology was used to biopsy 123 nodules; 201 nodules were biopsied by conventional fluoro-CT-guided technique. We assessed the performance of the two biopsy systems for diagnosis of malignancy and the radiation exposure.

resultsNodules biopsied by CBCT-guided and by fluoro-CT-guided technique had similar characteristics: size, 20 ± 6.5 mm (mean ± standard deviation) vs. 20 ± 6.8 mm (p = 0.845); depth from pleura, 15 ± 15 mm vs. 15 ± 16 mm (p = 0.595); malignant, 60% vs. 66% (p = 0.378). After a learning period, the newly introduced CBCT-guided biopsy system and the conventional fluoro-CT-guided system showed similar sensitivity (95% and 92%), specificity (100% and 100%), accuracy for diagnosis of malignancy (96% and 94%), and delivered non-significantly different median effective doses [11.1 mSv (95 % CI 8.9-16.0) vs. 14.5 mSv (95% CI 9.5-18.1); p = 0.330].

conclusionThe CBCT-guided and fluoro-CT-guided systems for lung nodule biopsy are similar in terms of diagnostic performance and effective dose, and may be alternatively used to optimize the available technological resources. KEY POINTS: • CBCT-guided and fluoro-CT-guided lung nodule biopsy provided high and similar diagnostic accuracy. • Effective dose from CBCT-guided and fluoro-CT-guided lung nodule biopsy was similar. • To optimize resources, CBCT-guided lung nodule biopsy may be an alternative to fluoro-CT-guided.

Indexed as

AdultAgedBiopsy, NeedleCone-Beam Computed TomographyFemaleFluoroscopyHumansImage-Guided BiopsyLung NeoplasmsMaleMiddle AgedRadiation DosageRadiography, InterventionalRetrospective StudiesSensitivity and SpecificityTomography, X-Ray ComputedC-arm cone-beam CTCT fluoroscopyLung nodule biopsyRadiation doseTransthoracic needle biopsy

Identifiers

PMID26045345
OpenAlexW618463975

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.