Evidence map›Paper›PMID 26045208›Full record

ArticlePediatric nephrology (Berlin, Germany)2015

Reduced taste function and taste papillae density in children with chronic kidney disease.

Maryam Correa, David G Laing, Ian Hutchinson, Anthony L Jinks, Jessica E Armstrong, Gad Kainer

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Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maryam CorreaChildren's Food Research and Education Unit, Centre for Advanced Food Research, College of Science, Technology and Environment, University of Western Sydney, Locked Bag 1797, Penrith South, NSW, 1797, Australia.
David G LaingChildren's Food Research and Education Unit, Centre for Advanced Food Research, College of Science, Technology and Environment, University of Western Sydney, Locked Bag 1797, Penrith South, NSW, 1797, Australia. d.laing@unsw.edu.au.
Ian HutchinsonChildren's Food Research and Education Unit, Centre for Advanced Food Research, College of Science, Technology and Environment, University of Western Sydney, Locked Bag 1797, Penrith South, NSW, 1797, Australia.
Anthony L JinksSchool of Psychology and Social Sciences, University of Western Sydney, Locked Bag 1797, Penrith South, 1797, NSW, Australia.
Jessica E ArmstrongSchool of Women's and Children's Health, Medicine, University of NSW, Level 3 Sydney Children's Hospital, High Street, Randwick, NSW, 2031, Australia.
Gad KainerSchool of Women's and Children's Health, Medicine, University of NSW, Level 3 Sydney Children's Hospital, High Street, Randwick, NSW, 2031, Australia.
Western Sydney University · AUSydney Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTaste loss may contribute to the loss of appetite in children with chronic kidney disease (CKD) and other serious medical conditions that result in malnutrition. Traditional methods for measurement of taste loss commonly use aqueous tastant solutions that can induce nausea, vomiting, or even pain in the mouth. An alternative is to measure fungiform papillae density on the anterior tongue since this correlates with taste sensitivity. Here we aimed to develop a non-invasive method for assessing papillae density on the anterior tongue and to use the method to determine if CKD patients [estimated glomerular filtrate (eGFR < 60 ml/min/1.73 m(2))] have a lower density than clinical controls (CC)(eGFR > 89 ml/min/1.73 m(2)).

methodsThirty-five healthy adults participated in the development of a method, which was assessed by 24 children, 12 of whom were CKD patients and 12 were clinical controls.

resultsSimilar papillae densities were found using invasive and non-invasive methods (F(1,34) = 0.647, p = 0.427). The CKD group had a significantly lower papillae density (X(2) = 7.17, p = 0.007) and poorer taste sensitivity than the CC group (p = 0.0272), and the density correlated significantly with eGFR (r = 0.56, p < 0.01).

conclusionsLoss of taste in children with CKD is due to the reduced number of papillae and their taste-sensing receptor cells.

Indexed as

AdolescentChildChild, PreschoolFemaleHumansMaleRenal Insufficiency, ChronicTaste BudsTaste DisordersTongueChildrenFungiform papillaeHistologyKidney diseaseTaste

Identifiers

PMID26045208
OpenAlexW595836049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.