ArticleBiomechanics and modeling in mechanobiology2016
A constitutive model for developing blood clots with various compositions and their nonlinear viscoelastic behavior.
Article in Biomechanics and modeling in mechanobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- A Comprehensive Numerical Model of Thrombus Embolization: Fluid-Thrombus Interactions Through a Coupled Computational Fluid Dynamics - Peridynamics Framework.Computer methods in applied mechanics and engineering · 2026Article
- Clots reveal anomalous elastic behavior of fiber networks.Science advances · 2024Article
- Quick model-based viscoelastic clot strength predictions from blood protein concentrations for cybermedical coagulation control.Nature communications · 2024Article
- Probing interactions of red blood cells and contracting fibrin platelet clots.Biophysical journal · 2023Article
- Liver Clot after Periodontal Surgery: A Rare Case Report.Journal of pharmacy & bioallied sciences · 2023Article
- Computational analysis of effects of clot length on Acute ischemic stroke recanalization under different cyclic aspiration loading conditions.International journal for numerical methods in biomedical engineering · 2023Article
- Passive high-frequency microrheology of blood.Soft matter · 2022Article
- Modeling acute ischemic stroke recanalization through cyclic aspiration.Journal of biomechanics · 2021Article
- Finite element analysis of blood clots based on the nonlinear visco-hyperelastic model.Biophysical journal · 2021Article
- Synthetic hydrogels as blood clot mimicking wound healing materials.Progress in biomedical engineering (Bristol, England) · 2021Article
- Blood Clot Phenotyping by Rheometry: Platelets and Fibrinogen Chemistry Affect Stress-Softening and -Stiffening at Large Oscillation Amplitude.Molecules (Basel, Switzerland) · 2020Article
- A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.PLoS computational biology · 2020Article
- In vivo measurement of blood clot mechanics from computational fluid dynamics based on intravital microscopy images.Computers in biology and medicine · 2019Article
- Modeling Ramp-hold Indentation Measurements based on Kelvin-Voigt Fractional Derivative Model.Measurement science & technology · 2018Article
- Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow.Journal of the Royal Society, Interface · 2017Article
- Fibrin mechanical properties and their structural origins.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Buffers Strongly Modulate Fibrin Self-Assembly into Fibrous Networks.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Assessing composition and structure of soft biphasic media from Kelvin-Voigt fractional derivative model parameters.Measurement science & technology · 2017Article
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4 authors.
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Abstract
The mechanical properties determine to a large extent the functioning of a blood clot. These properties depend on the composition of the clot and have been related to many diseases. However, the various involved components and their complex interactions make it difficult at this stage to fully understand and predict properties as a function of the components. Therefore, in this study, a constitutive model is developed that describes the viscoelastic behavior of blood clots with various compositions. Hereto, clots are formed from whole blood, platelet-rich plasma and platelet-poor plasma to study the influence of red blood cells, platelets and fibrin, respectively. Rheological experiments are performed to probe the mechanical behavior of the clots during their formation. The nonlinear viscoelastic behavior of the mature clots is characterized using a large amplitude oscillatory shear deformation. The model is based on a generalized Maxwell model that accurately describes the results for the different rheological experiments by making the moduli and viscosities a function of time and the past and current deformation. Using the same model with different parameter values enables a description of clots with different compositions. A sensitivity analysis is applied to study the influence of parameter variations on the model output. The relative simplicity and flexibility make the model suitable for numerical simulations of blood clots and other materials showing similar behavior.
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