Evidence map›Paper›PMID 26045103›Full record

ReviewCurrent genetics2016

Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system.

Nana Yang, Lefu Lan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Regulatory effects on virulence and phage susceptibility revealed byFrontiers in cellular and infection microbiology · 2025
    Article
  3. Article
  4. Review
  5. Microbiology spectrum · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Rewiring of Gene Expression inFrontiers in microbiology · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nana YangShanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong Zhangjiang Hi-Tech Park, Shanghai, 201203, China.
Lefu LanShanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong Zhangjiang Hi-Tech Park, Shanghai, 201203, China. llan@simm.ac.cn.
Shanghai Institute of Materia Medica · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing (QS) plays critical roles in virulence gene expression and the pathogenesis of Pseudomonas aeruginosa, an important human pathogen. However, the regulatory effects, especially that occur directly upstream of the QS system, remain largely unknown. Here, we review recent advances in the understanding of the key component of carbon catabolite repression (CCR) system and protein quality control (PQC) system in regulating the QS system in P. aeruginosa. We propose that PQC proteases Lon and ClpXP may have an important role in linking CCR with QS, and thus contribute to the integration of nutritional cues into the regulatory network governing the virulence factors expression in P. aeruginosa.

Indexed as

Adenosine TriphosphateCarbonCatabolite RepressionEndopeptidase ClpHumansProtease LaPseudomonas aeruginosaQuorum SensingAdenosine TriphosphateCarbonEndopeptidase ClpProtease LaCarbon catabolite repressionClpLonPseudomonas aeruginosaQuorum sensing

Identifiers

PMID26045103
OpenAlexW624788065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.