Evidence map›Paper›PMID 26045097›Full record

ArticleSurgical endoscopy2016

Quality of life in non-early rectal cancer treated by neoadjuvant radio-chemotherapy and endoluminal loco-regional resection (ELRR) by transanal endoscopic microsurgery (TEM) versus laparoscopic total mesorectal excision.

Giancarlo D'Ambrosio, Alessandro M Paganini, Andrea Balla, Silvia Quaresima, Pietro Ursi, Paolo Bruzzone, Andrea Picchetto, Fabrizio I Mattei, Emanuele Lezoche

Registry-linked trialAbstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04455945 (Comparison of Quality of Life Outcomes Between Laparoscopic and Open Approach for Rectal Cancer Surgery), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04455945 completednot on this mapstarted 2017, after this paper: background citation

Comparison of Quality of Life Outcomes Between Laparoscopic and Open Approach for Rectal Cancer Surgery

Typeobservational_patient_registrySponsorDr. Lutfi Kirdar Kartal Training and Research HospitalRan2017 to 2020Enrolled2ConditionsRectal Cancer, Quality of LifeArmsOpen Rectal cancer surgery, Laparoscopic Rectal cancer surgery
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Observational
  9. Transanal endoscopic microsurgery: exploring its indications and novel applications. A narrative review.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Chemoradiation and Local Excision for T2N0 Rectal Cancer Offers Equivalent Overall Survival Compared to Standard Resection: a National Cancer Database Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giancarlo D'AmbrosioDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy. giancarlodambrosio@libero.it.
Alessandro M PaganiniDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Andrea BallaDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy. andrea.balla@gmail.com.
Silvia QuaresimaDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Pietro UrsiDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Paolo BruzzoneDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Andrea PicchettoDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Fabrizio I MatteiDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Emanuele LezocheDepartment of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn selected patients with N0 rectal cancer, endoluminal loco-regional resection (ELRR) by transanal endoscopic microsurgery (TEM) may be an alternative treatment option to laparoscopic total mesorectal excision (LTME). Aim of this study is to evaluate the short- and medium-term quality of life (QoL) from a retrospective analysis of prospectively collected data in patients with iT2-iT3 N0-N+ rectal cancer, who underwent ELRR by TEM or LTME after neoadjuvant radio-chemotherapy (n-RCT).

methodsThirty patients with iT2-iT3 rectal cancer who underwent ELRR by TEM (n = 15) or LTME (n = 15) were enrolled in this study. The choice for one operation or the other was made on the basis of predefined criteria. QoL was evaluated by EORTC QLQ-C30 and QLQ-CR38 questionnaires at admission, after n-RCT and 1, 6, and 12 months after surgery.

resultsNo statistically significant differences in QoL evaluation were observed between the two groups, both at admission and after n-RCT. At 1 month after surgery, significantly better results in the ELRR group were observed by QLQ-C30 in: Nausea/Vomiting (p = 0.05), Appetite Loss (p = 0.003), Constipation (p = 0.05), and by QLQ-CR38 in: Body Image (p = 0.05), Sexual Functioning (p = 0.03), Future Perspective (p = 0.05) and Weight Loss (p = 0.036). At 6 months after surgery, a statistically significant worse impact after LTME was observed by QLQ-C30 in: Global Health Status (p = 0.05), Emotional Functioning (p = 0.021), Dyspnea (p = 0.008), Insomnia (p = 0.012), Appetite Loss (p = 0.014) and by QLQ-CR38 in Body Image (p = 0.05) and Defecation Problems (p = 0.001). At 1 year, the two groups were homogenous as assessed by QLQ-C30, whereas the QLQ-CR38 still showed better results of ELRR versus LTME in Body Image (p = 0.006), Defecation Problems (p = 0.01), and Weight Loss (p = 0.005).

conclusionsBased on the present series, in selected patients, earlier restoration of patients' functions is observed after ELRR by TEM than after LTME.

Indexed as

Chemoradiotherapy, AdjuvantNeoadjuvant TherapyQuality of LifeTransanal Endoscopic MicrosurgeryAdultAgedAged, 80 and overFemaleHumansLaparoscopyMaleMiddle AgedNeoplasm StagingRectal NeoplasmsRectumRetrospective StudiesEndoluminal loco-regional resection (ELRR)Laparoscopic total mesorectal excision (LTME)Neoadjuvant radio-chemotherapy (n-RCT)Quality of life (QoL)Rectal cancerTransanal endoscopic microsurgery (TEM)

Identifiers

PMID26045097
OpenAlexW571594433

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.