Evidence map›Paper›PMID 26044792›Full record

ArticleThe Journal of general virology2015

Exploring the virome of diseased horses.

Linlin Li, Federico Giannitti, Jason Low, Casey Keyes, Leila S Ullmann, Xutao Deng, Monica Aleman, Patricia A Pesavento, Nicola Pusterla, Eric Delwart

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 112 citations in OpenAlex.

  1. Article
  2. Picobirnavirus: how do you find where it's hiding?Critical reviews in microbiology · 2026
    Review
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  16. Vertebrate-tropism of a cressdnavirus lineage implicated by poxvirus gene capture.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Linlin LiBlood Systems Research Institute, San Francisco, CA, USA.
Federico GiannittiCalifornia Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, CA, USA.
Jason LowDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Casey KeyesDepartment of Biology, University of San Francisco, San Francisco, CA, USA.
Leila S UllmannDepartment of Microbiology and Immunology, UNESP Sao Paulo State University, Sao Paulo, Brazil.
Xutao DengBlood Systems Research Institute, San Francisco, CA, USA.
Monica AlemanDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA.
Patricia A PesaventoDepartment of Pathology, Microbiology and Immunology, University of California, Davis, CA, USA.
Nicola PusterlaDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA.
Eric DelwartBlood Systems Research Institute, San Francisco, CA, USA.
University of California, Davis · USBlood Systems Research Institute · USInstituto Nacional de Investigación Agropecuaria · UYUniversidade Estadual Paulista (Unesp) · BRUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of San Francisco · US

Funding

Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
NHLBI NIH HHS R01 HL105770
6 · The paper itself

Abstract

Metagenomics was used to characterize viral genomes in clinical specimens of horses with various organ-specific diseases of unknown aetiology. A novel parvovirus as well as a previously described hepacivirus closely related to human hepatitis C virus and equid herpesvirus 2 were identified in the cerebrospinal fluid of horses with neurological signs. Four co-infecting picobirnaviruses, including an unusual genome with fused RNA segments, and a divergent anellovirus were found in the plasma of two febrile horses. A novel cyclovirus genome was characterized from the nasal secretion of another febrile animal. Lastly, a small circular DNA genome with a Rep gene, from a virus we called kirkovirus, was identified in the liver and spleen of a horse with fatal idiopathic hepatopathy. This study expands the number of viruses found in horses, and characterizes their genomes to assist future epidemiological studies of their transmission and potential association with various equine diseases.

Indexed as

AnimalsGenome, ViralHorse DiseasesHorsesHumansMetagenomicsMolecular Sequence DataPhylogenyVirus DiseasesViruses

Identifiers

PMID26044792
PMCPMC4635498
OpenAlexW657306922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.