Evidence map›Paper›PMID 26044778›Full record

ArticleMolecular medicine reports2015

Profiling circulating microRNAs in maternal serum and plasma.

Qinyu Ge, Yanting Shen, Fei Tian, Jiafeng Lu, Yunfei Bai, Zuhong Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qinyu GeKey Lab for Child Development and Learning Science, Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Yanting ShenKey Lab for Child Development and Learning Science, Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Fei TianKey Lab for Child Development and Learning Science, Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Jiafeng LuState Key Laboratory of Bioelectronics, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Yunfei BaiState Key Laboratory of Bioelectronics, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Zuhong LuKey Lab for Child Development and Learning Science, Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, Jiangsu 210096, P.R. China.
Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum and plasma are two of the most commonly used materials in clinical diagnosis and investigations. Whether differential nucleic acids exist between the serum and plasma, and the way in which they may be selected in clinical diagnosis and applications remains to be elucidated. The present study sequenced microRNAs (miRNAs) in the serum and plasma of pregnant females using next generation sequencing technology. Several differentially expressed miRNAs were also verified by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). In total, 329 miRNAs and 193 miRNAs were detected in maternal serum and plasma. Differential expression and different types of miRNAs were found in the serum and plasma, among them, 19 were upregulated and 6 were downregulated in serum when compared with plasma with a fold change >2.0 (P<0.001). The results demonstrated that a number of miRNAs were differentially expressed in the serum and plasma, and several of the miRNAs expressed in the serum were absent in the plasma. The results obtained using RT‑qPCR in the selected miRNAs were similar to these results, and indicated that the differential expression of miRNAs in the serum and plasma provide a guide for further investigation and clinical use. The results of the analysis also suggested that differentially expressed DNA and RNA in the serum and plasma of pregnant females may be a result of the differential expression of miRNAs.

Indexed as

FemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansMicroRNAsPregnancyReverse Transcriptase Polymerase Chain ReactionMicroRNAs

Identifiers

PMID26044778
PMCPMC4526092
OpenAlexW1945950103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.