ArticleInternational archives of allergy and immunology2015
Infection with Rhinovirus Facilitates Allergen Penetration Across a Respiratory Epithelial Cell Layer.
Article in International archives of allergy and immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05042830 (Contribution of Local Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Production Upon Nasal Allergen Contact - an Explorative Pilot Study), which is not on this map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Contribution of Local Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Production Upon Nasal Allergen Contact - an Explorative Pilot Study
Who cites it
16 citing papers in PubMed.
- Bispecific nanobodies targeting Bet v 1 and ICAM-1 decrease respiratory epithelial penetration of Bet v 1.Frontiers in immunology · 2026Article
- The role of virus in nasal inflammation.European journal of medical research · 2025Review
- Association between asthma and IgG levels specific for rhinovirus and respiratory syncytial virus antigens in children and adults.The journal of allergy and clinical immunology. Global · 2025Article
- Risk factors of allergic rhinitis and its prevention strategies.Frontiers in allergy · 2024Review
- EPsInternational journal of molecular sciences · 2023Article
- Antibody Conjugates Bispecific for Pollen Allergens and ICAM-1 with Potential to Prevent Epithelial Allergen Transmigration and Rhinovirus Infection.International journal of molecular sciences · 2023Article
- Generation of high affinity ICAM-1-specific nanobodies and evaluation of their suitability for allergy treatment.Frontiers in immunology · 2022Article
- Article
- Epithelial Barrier Dysfunction in Chronic Respiratory Diseases.Frontiers in physiology · 2021Review
- Review: The Nose as a Route for Therapy. Part 2 Immunotherapy.Frontiers in allergy · 2021Review
- Fish-derived low molecular weight components modify bronchial epithelial barrier properties and release of pro-inflammatory cytokines.Molecular immunology · 2019Article
- Knob protein enhances epithelial barrier integrity and attenuates airway inflammation.The Journal of allergy and clinical immunology · 2018Article
- Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function.Scientific reports · 2018Article
- Human bocavirus 1 infection of CACO-2 cell line cultures.Virology · 2017Article
- Mucosal Lining Fluid Biomarkers in Asthma: Basis for Rational Use of New Targeted Therapies?EBioMedicine · 2017Article
- Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundRhinovirus infections are a major risk factor for asthma exacerbations. We sought to investigate in an in vitro system whether infection with human rhinovirus reduces the integrity and barrier function of a respiratory epithelial cell layer and thus may influence allergen penetration.
methodsWe cultured the human bronchial epithelial cell line 16HBE14o- in a transwell culture system as a surrogate of respiratory epithelium. The cell monolayer was infected with human rhinovirus 14 at 2 different doses. The extent and effects of transepithelial allergen penetration were assessed using transepithelial resistance measurements and a panel of (125)I-labeled purified recombinant respiratory allergens (rBet v 1, rBet v 2, and rPhl p 5).
resultsInfection of respiratory cell monolayers with human rhinovirus decreased transepithelial resistance and induced a pronounced increase in allergen penetration.
conclusionsOur results indicate that infection with rhinovirus damages the respiratory epithelial barrier and allows allergens to penetrate more efficiently into the subepithelial tissues where they may cause increased allergic inflammation.
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