ReviewAesthetic plastic surgery2015
Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature.
Review in Aesthetic plastic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Pooled it
- Platelet rich plasma for facial rejuvenation: an overview of systematic reviews.Blood transfusion = Trasfusione del sangue · 2024Pooled it
- Injections of platelet-rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Trial
- Trial
- Platelet-rich plasma in the management of diabetic foot ulcers (Review).Biomedical reports · 2026Review
- Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia.Drug delivery and translational research · 2025Article
- Use of platelet rich plasma for skin rejuvenation.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Review
- Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature.Aesthetic plastic surgery · 2024Article
- Status of research on the development and regeneration of hair follicles.International journal of medical sciences · 2024Review
- Current and Future Developments in Wound Healing.Facial plastic surgery : FPS · 2023Article
- Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis.Biomedicines · 2023Review
- The Application of Platelet-Rich Plasma for Patients Following Total Joint Replacement: A Meta-Analysis of Randomized Controlled Trials and Systematic Review.Frontiers in surgery · 2022Review
- Platelet Rich Plasma and Its Use in Hair Regrowth: A Review.Drug design, development and therapy · 2022Review
- Autologous platelet concentrates for facial rejuvenation.Journal of applied oral science : revista FOB · 2022Review
- Platelet-Rich Plasma Facial Rejuvenation: Myth or Reality?Aesthetic plastic surgery · 2021Review
- Regenerative and stem cell-based techniques for facial rejuvenation.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Platelet-rich Plasma use for facial rejuvenation: a clinical trial and review of current literature.Acta bio-medica : Atenei Parmensis · 2021Article
- Platelet-rich plasma for laryngotracheal reconstruction: an experimental study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Use of platelet-rich plasma to facilitate wound healing.International wound journal · 2019Article
- Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model.Stem cells international · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included. Thirteen in vitro studies showed use of platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) had a significant effect on cellular activity. Twenty-four out of 28 animal studies exhibited favorable results with use of a platelet preparation, including five of six studies that showed enhanced fat graft survival with addition of a platelet preparation. Twenty-three case series and clinical trials were identified, only two of which showed no differences. Twenty-one reported favorable results with use of various platelet preparations. A total of 47 studies used PRP, four studies evaluated Leukocyte-rich PRP, and fourteen studies used PRFM. The vast majority of studies examined show a significant and measurable effect on cellular changes, wound healing, and facial esthetic outcomes with use of platelet preparations, both topical and injectable. One must also consider possible publication bias against null results that may have had an influence on the data that were available for review. However, the preponderance of studies suggests that platelet preparations might represent an as-of-yet untapped adjunct in facial plastic surgery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.