Evidence map›Paper›PMID 26044200›Full record

ArticleMuscle & nerve2016

PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection.

Jung A Kim, Roland R Roy, Hui Zhong, William A Alaynick, Emi Embler, Claire Jang, Gabriel Gomez, Takuma Sonoda, Ronald M Evans, V Reggie Edgerton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Sarcopenia and Muscle Aging: A Brief Overview.Endocrinology and metabolism (Seoul, Korea) · 2020
    Review
  2. Fiber Type-Specific Morphological and Cellular Changes of Paraspinal Muscles in Patients with Severe Adolescent Idiopathic Scoliosis.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  3. Article
  4. Mitochondrial health and muscle plasticity after spinal cord injury.European journal of applied physiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jung A KimDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
Roland R RoyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
Hui ZhongDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
William A AlaynickGene Expression Laboratory, Salk Institute, La Jolla, California, USA.
Emi EmblerGene Expression Laboratory, Salk Institute, La Jolla, California, USA.
Claire JangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
Gabriel GomezDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
Takuma SonodaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute, La Jolla, California, USA.
V Reggie EdgertonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
University of California, Los Angeles · USSalk Institute for Biological Studies · USCharles R. Drew University of Medicine and Science · US

Funding

HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0M
Spatial Regulation of Developmental Gene ExpressionR01HL105278 · NHLBI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2011 to 2019
$4.0M
Hormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6M
Howard Hughes Medical InstituteNHLBI NIH HHS HL105278NHLBI NIH HHS R01 HL105278NIDDK NIH HHS DK057978NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R37 DK057978
6 · The paper itself

Abstract

introductionSkeletal muscle oxidative capacity decreases and fatigability increases after spinal cord injury. Transcription factor peroxisome proliferator-activated receptor δ (PPARδ) promotes a more oxidative phenotype.

methodsWe asked whether PPARδ overexpression could ameliorate these deficits in the medial gastrocnemius of spinal cord transected (ST) adult mice.

resultsTime-to-peak tension and half-relaxation times were longer in PPARδ-Con and PPARδ-ST compared with littermate wild-type (WT) controls. Fatigue index was 50% higher in PPARδ-Con than WT-Con and 70% higher in the PPARδ-ST than WT-ST. There was an overall higher percent of darkly stained fibers for succinate dehydrogenase in both PPARδ groups.

conclusionsThe results indicate a conversion toward slower, more oxidative, and less fatigable muscle properties with overexpression of PPARδ. Importantly, the elevated fatigue resistance was maintained after ST, suggesting that enhanced PPARδ expression, and possibly small molecule agonists, could ameliorate the increased fatigability routinely observed in chronically paralyzed muscles.

Indexed as

AnimalsBody WeightDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicMuscle FatigueMuscle, SkeletalMyosin Heavy ChainsOrgan SizePPAR alphaRNA, MessengerSpinal Cord InjuriesStatistics, NonparametricMyosin Heavy ChainsPPAR alphaRNA, MessengerSuccinate Dehydrogenasefatigabilityisometric contractile propertiesmyosin heavy chainoxidative metabolismspinal cord injury

Identifiers

PMID26044200
PMCPMC4670275
OpenAlexW2145995432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.