ArticleCancer research and treatment2016
Appendiceal Neuroendocrine, Goblet and Signet-Ring Cell Tumors: A Spectrum of Diseases with Different Patterns of Presentation and Outcome.
Article in Cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Survival and prognostic differences between appendiceal NETs and goblet cell adenocarcinomas.Endocrine oncology (Bristol, England) · 2025Article
- PostoperativeANZ journal of surgery · 2024Article
- Right Hemicolectomy and Appendicectomy as Treatments for Goblet Cell Adenocarcinoma: A Comparative Analysis of Two Large National Databases.Current oncology (Toronto, Ont.) · 2024Article
- Incidental Detection and Management of a Neuroendocrine Carcinoid Tumor of the Appendix in a Young Male Patient.Cureus · 2023Article
- Review
- Collision Tumor of the Appendix.Cureus · 2023Article
- Appendiceal goblet cell carcinoma has marginal advantages from perioperative chemotherapy: a population-based study with an entropy balancing analysis.Langenbeck's archives of surgery · 2023Article
- An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.World journal of surgery · 2022Article
- New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastroenterology · 2022Review
- Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry.Frontiers in oncology · 2022Article
- Omission of Right Hemicolectomy May be Safe for Some Appendiceal Goblet Cell Adenocarcinomas: A Survival Analysis of the National Cancer Database.Annals of surgical oncology · 2021Article
- Article
- Survival Profile and Prognostic Factors for Appendiceal Mixed Neuroendocrine Non-neuroendocrine Neoplasms: A SEER Population-Based Study.Frontiers in oncology · 2020Article
- A Case of Appendiceal Goblet Cell Carcinoid Tumor: Getting it right under the Microscope.Journal of the ASEAN Federation of Endocrine Societies · 2020Article
- Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study.International journal of colorectal disease · 2019Article
- Goblet cell carcinoid of the appendix - diagnostic challenges and treatment updates: a case report and review of the literature.Journal of medical case reports · 2018Review
- Appendiceal Neoplasms.Clinics in colon and rectal surgery · 2018Review
- Prognostic value of chromogranin A in patients with GET/NEN in the pancreas and the small intestine.Endocrine connections · 2018Article
- Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies.World journal of gastrointestinal surgery · 2016Review
- [Classification and clinicopathological characteristics of gastroenteropancreatic neuroendocrine neoplasms].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAppendiceal tumors are a heterogeneous group of diseases that include typical neuroendocrine tumors (TNET), goblet cell carcinoids (GCC), and atypical GCC. Atypical GCC are classified into signet-ring cell cancers (SRCC) and poorly differentiated appendiceal adenocarcinoids. The prognosis and management of these diseases is unclear because there are no prospective studies. The aim of this study is to assess the characteristics and outcome of appendiceal TNET, GCC, and SRCC patients. MATERIALS AND
methodsAppendiceal TNET, GCC, and SRCC patients diagnosed between 1973 and 2011 were identified in the Surveillance Epidemiology and End Results (SEER) database. Demographics, type of surgery, and clinicopathologic characteristics were collected. Survival functions were estimated by the Kaplan-Meier method, and log-rank test was used to assess the difference in overall survival (OS) among the three histologies.
resultsThe SEER database yielded 1,021 TNET patients, 1,582 with GCC, and 534 SRCC patients. TNET presented at a younger age (p < 0.001). Patients with SRCC presented with advanced stage disease (p < 0.001). The median OS (mOS) for GCC and TNET patients was not reached; mOS for SRCC was 24 months. Multivariate analysis stratified for stage revealed significantly longer survival for TNET and GCC than SRCC (p < 0.001).
conclusionThis is the largest report to date for appendiceal neuroendocrine tumor patients, suggesting a spectrum of diseases with different characteristics and outcomes. In this report, we present a treatment approach for this complex spectrum of disease, based on the experience of Ohio State and Emory Universities investigators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.