ArticleOncology reports2015
Rearrangement of chromosome bands 12q14~15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma.
Article in Oncology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Genetic Characterization of Myoid Hamartoma of the Breast.Cancer genomics & proteomicsTrial
- Acral Mesenchymal Spindle Cell Neoplasm With a Novel HMGA2::NCOA2 Fusion.Journal of cutaneous pathology · 2026Article
- Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Whole‑exome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family.Molecular medicine reports · 2020Article
- High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia.International journal of molecular sciences · 2020Review
- Mesenchymal tumors of the lung: diagnostic pathology, molecular pathogenesis, and identified biomarkers.Journal of thoracic disease · 2019Review
- Genetic heterogeneity in leiomyomas of deep soft tissue.Oncotarget · 2017Article
- Differences in molecular regulation between osteochondroma and bizarre parosteal osteochondromatous proliferation.Molecular medicine reports · 2017Article
- Article
- The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.Cancer letters · 2016Article
- NFAT restricts osteochondroma formation from entheseal progenitors.JCI insight · 2016Article
- Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14).Diagnostic pathology · 2016Article
- Fusion of theCancer genomics & proteomicsArticle
- Article
- RareCancer genomics & proteomicsReview
- Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (Cancer genomics & proteomicsArticle
- Article
- Presence of a t(12;18)(q14;q21) Chromosome Translocation and Fusion of the Genes for High-mobility Group AT-Hook 2 (Cancer genomics & proteomicsArticle
- A Novel Cryptic t(2;3)(p21;q25) Translocation Fuses theCancer genomics & proteomicsArticle
- Neoplasia-associated Chromosome Translocations Resulting in Gene Truncation.Cancer genomics & proteomicsReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe two cases of extraskeletal osteochondroma in which chromosome bands 12q14~15 were visibly rearranged through a pericentric inv(12). Molecular analysis of the first tumor showed that both transcript 1 (NM_003483) and transcript 2 (NM_003484) of HMGA2 were expressed. In the second tumor, the inv(12) detected by karyotyping had resulted in an HMGA2-SOX5 fusion transcript in which exons 1-3 of HMGA2 were fused with a sequence from intron 1 of SOX5. The observed pattern is similar to rearrangements of HMGA2 found in several other benign mesenchymal tumors, i.e., disruption of the HMGA2 locus leaves intact exons 1-3 which encode the AT-hook domains and separates them from the 3'-terminal part of the gene. Our data therefore show that a subset of soft tissue osteochondromas shares pathogenetic involvement of HMGA2 with lipomas, leiomyomas and other benign connective tissue neoplasms.
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