Evidence map›Paper›PMID 26043420›Full record

ReviewDeutsches Arzteblatt international2015

Hoarseness-causes and treatments.

Rudolf Reiter, Thomas Karl Hoffmann, Anja Pickhard, Sibylle Brosch

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03690284 (The VivaSight Double Lumen Tube Versus Conventional Double Lumen Tube in Thoracic Surgical Patients), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03690284 nacompletednot on this mapstarted 2019, after this paper: background citation

The VivaSight Double Lumen Tube Versus Conventional Double Lumen Tube in Thoracic Surgical Patients

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2019 to 2020Enrolled50ConditionsDouble Lumen Endotracheal Tube, Single Lung VentilationArmsConventional Double Lumen Tube, VivaSight Double Lumen Tube
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 77 citations in OpenAlex.

  1. Detection of macula flava cells proliferation after vocal fold injury.Brazilian journal of otorhinolaryngology · 2026
    Article
  2. Review
  3. Misuse of Steroids in Hoarseness of Voice: A Retrospective Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  4. Ear, nose and throat disorders and international travel.Tropical diseases, travel medicine and vaccines · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. The effectiveness of various treatment approaches for laryngeal contact granulomas.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  10. Article
  11. Article
  12. Expanded taxonomies of human memory.Frontiers in cognition · 2024
    Review
  13. The accuracy of an Online Sequential Extreme Learning Machine in detecting voice pathology using the Malaysian Voice Pathology Database.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023
    Article
  14. Article
  15. A Rare Case of Laryngeal Hamartoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  16. Article
  17. Alarming triad of progressive hoarseness in a male smoker.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Rudolf ReiterDivision of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Hospital, Ulm, Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Hospital, Ulm, Department of Otorhinolaryngology, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich.
Thomas Karl Hoffmann
Anja Pickhard
Sibylle Brosch
Klinikum rechts der Isar · DETechnical University of Munich · DEUniversity Hospital Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHoarseness (dysphonia) is the reason for about 1% of all consultations in primary care. It has many causes, ranging from self-limited laryngitis to malignant tumors of the vocal cords.

methodsThis review is based on literature retrieved by a selective search in PubMed employing the terms "hoarseness," "hoarse voice," and "dysphonia," on the relevant guideline of the American Academy of Otolaryngology -Head and Neck Surgery, and on Cochrane reviews.

resultsHoarseness can be caused by acute (42.1%) and chronic laryngitis (9.7%), functional vocal disturbances (30%), and benign (10.7-31%) and malignant tumors (2.2-3%), as well as by neurogenic disturbances such as vocal cord paresis (2.8-8%), physiologic aging of the voice (2%), and psychogenic factors (2-2.2 %). Hoarseness is very rarely a manifestation of internal medical illness. The treatment of hoarseness has been studied in only a few randomized controlled trials, all of which were on a small scale. Voice therapy is often successful in the treatment of functional and organic vocal disturbances (level 1a evidence). Surgery on the vocal cords is indicated to treat tumors and inadequate vocal cord closure. The only entity causing hoarseness that can be treated pharmacologically is chronic laryngitis associated with gastro-esophageal reflux, which responds to treatment of the reflux disorder. The empirical treatment of hoarseness with antibiotics or corticosteroids is not recommended.

conclusionVoice therapy, vocal cord surgery, and drug therapy for appropriate groups of patients with hoarseness are well documented as effective by the available evidence. In patients with risk factors, especially smokers, hoarseness should be immediately evaluated by laryngos - copy.

Indexed as

Diagnosis, DifferentialEvidence-Based MedicineHoarsenessHumansLaryngeal NeoplasmsLaryngitisLaryngoscopyTreatment OutcomeVocal Cord Paralysis

Identifiers

PMID26043420
PMCPMC4458789
OpenAlexW786149580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.