Evidence map›Paper›PMID 26043417›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2015

Neonatal nasal intermittent positive pressure ventilation efficacy and lung pressure transmission.

A Mukerji, J Belik

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Comparison of two different Nasal Interfaces used in Non-Invasive Respiratory support in terms of Neonate comfort.Malawi medical journal : the journal of Medical Association of Malawi · 2024
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  16. Continuous positive airway pressure delivery during less invasive surfactant administration: a physiologic study.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
  17. [Research advances in neonatal nasal intermittent positive pressure ventilation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017
    Review
  18. [Research advances in noninvasive high-frequency oscillatory ventilation in neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017
    Review
  19. Review
  20. Impact of interprofessional education on noninvasive ventilation in a tertiary neonatal intensive care unit.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

A MukerjiDivision of Neonatology, Department of Paediatrics, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
J BelikDepartment of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to evaluate carbon dioxide (CO2) clearance, delivered pressures and tidal volume (VT) during neonatal nasal intermittent positive pressure ventilation (NIPPV) with two commonly used interfaces. STUDY

designA neonatal lung model, with either short binasal prongs (SBP) or a small caliber nasal cannula (RAM) interface, was tested over a range of clinically relevant settings. A fixed amount of CO2 was infused and the fraction remaining in the lung 100 s postinfusion was measured. Pressure transmission to the lung and VT was measured at the level of the trachea.

resultCO2 elimination was directly proportional to the inspiratory pressure during NIPPV. At peak pressures of 22 to 34 cm H2O, CO2 clearance was greater (P<0.001) with SBP as compared with RAM. Relative to the set ventilator parameters, a substantial pressure dampening effect was documented at the lung level, which was significantly lower with RAM when compared with SBP (2.8% (0.2) versus 11.9% (1.5), P<0.0001). CO2 elimination was dependent on VT and effective despite only a small fraction of physiological VT (maximum delivered VT%: SBP 15.5 (0.7) versus RAM 6.1 (1.4), P<0.0001).

conclusionNIPPV promotes CO2 elimination even at low transmitted airway pressures, but less effective with RAM as compared with SBP. CO2 elimination despite small VT suggests that NIPPV may depend on a non-conventional gas-exchange mechanism.

Indexed as

Intermittent Positive-Pressure VentilationCarbon DioxideHumansInfant, NewbornInfant, Newborn, DiseasesManikinsPulmonary Gas ExchangeTidal VolumeVentilator-Induced Lung InjuryVentilators, MechanicalCarbon Dioxide

Identifiers

PMID26043417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.