ArticlePloS one2015
Novel epigenetic changes unveiled by monozygotic twins discordant for smoking habits.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Multiomics Analysis of Skeletal Muscle Identifies Dysregulation of Hypoxia-Induced Genes in Peripheral Artery Disease.Journal of the American Heart Association · 2025Article
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- Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes.Clinical epigenetics · 2023Article
- A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events.Clinical epigenetics · 2022Article
- The association between DNA methylation of 6p21.33 and AHRR in blood and coronary heart disease in Chinese population.BMC cardiovascular disorders · 2022Article
- Cigarette smoke-induced alterations in blood: A review of research on DNA methylation and gene expression.Experimental and clinical psychopharmacology · 2021Review
- Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility.Epigenetics · 2020Article
- Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes.Frontiers in public health · 2020Review
- Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population.PloS one · 2020Article
- Validated inference of smoking habits from blood with a finite DNA methylation marker set.European journal of epidemiology · 2019Article
- Identification of novel pathogenic MSH2 mutation and new DNA repair genes variants: investigation of a Tunisian Lynch syndrome family with discordant twins.Journal of translational medicine · 2019Article
- Establishing a generalized polyepigenetic biomarker for tobacco smoking.Translational psychiatry · 2019Article
- Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci.Clinical epigenetics · 2019Article
- Article
- Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study.Clinical epigenetics · 2018Article
- The signature of liver cancer in immune cells DNA methylation.Clinical epigenetics · 2018Article
- From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence.Genome biology · 2017Article
- Epigenetic Modifications and Therapy in Multiple Sclerosis.Neuromolecular medicine · 2017Review
- Article
- The Inflammatory Response in Psoriasis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to cigarette smoking affects the epigenome and could increase the risk of developing diseases such as cancer and cardiovascular disorders. Changes in DNA methylation associated with smoking may help to identify molecular pathways that contribute to disease etiology. Previous studies are not completely concordant in the identification of differentially methylated regions in the DNA of smokers. We performed an epigenome-wide DNA methylation study in a group of monozygotic (MZ) twins discordant for smoking habits to determine the effect of smoking on DNA methylation. As MZ twins are considered genetically identical, this model allowed us to identify smoking-related DNA methylation changes independent from genetic components. We investigated the whole blood genome-wide DNA methylation profiles in 20 MZ twin pairs discordant for smoking habits by using the Illumina HumanMethylation450 BeadChip. We identified 22 CpG sites that were differentially methylated between smoker and non-smoker MZ twins by intra-pair analysis. We confirmed eight loci already described by other groups, located in AHRR, F2RL3, MYOG1 genes, at 2q37.1 and 6p21.33 regions, and also identified several new loci. Moreover, pathway analysis showed an enrichment of genes involved in GTPase regulatory activity. Our study confirmed the evidence of smoking-related DNA methylation changes, emphasizing that well-designed MZ twin models can aid the discovery of novel DNA methylation signals, even in a limited sample population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.