ArticleNutrients2015
Zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Mechanistic Insights into Antioxidant Interventions Targeting Obesity-Induced Oxidative Stress in the Pathogenesis and Complications of Type 2 Diabetes Mellitus.Current issues in molecular biology · 2025Review
- Assessment of trace element imbalances in diabetes mellitus patients with and without diabetic retinopathy: a case-control study in Iraq.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Assessment of health-related quality of life in transfusion dependent beta thalassemia.Scientific reports · 2025Article
- Growth and endocrinopathies among children with β-Thalassemia major treated at Dubai Thalassemia centre.BMC pediatrics · 2024Observational
- Two risk factors for hypozincemia in diabetic β-thalassemia patients: Hepatitis C and deferasirox.PloS one · 2024Article
- A prospective guide for clinical implementation of selected OGTT- derived surrogate indices for the evaluation of β- cell function and insulin sensitivity in patients with transfusion-dependent β- thalassaemia.Acta bio-medica : Atenei Parmensis · 2023Article
- The effects of excess weight on glucose homeostasis in young adult females with β-thalassemia major (β-TM): a preliminary retrospective study.Acta bio-medica : Atenei Parmensis · 2023Observational
- Ameliorative effects of zinc supplementation on cognitive function and hippocampal leptin signaling pathway in obese male and female rats.Scientific reports · 2023Article
- Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review).Experimental and therapeutic medicine · 2022Review
- Screening for glucose dysregulation in β-thalassemia major (β-TM): An update of current evidences and personal experience.Acta bio-medica : Atenei Parmensis · 2022Article
- The effect of zinc deficiency and iron overload on endocrine and exocrine pancreatic function in children with transfusion-dependent thalassemia: a cross-sectional study.BMC pediatrics · 2021Article
- Using LIBS as a diagnostic tool in pediatrics beta-thalassemia.Lasers in medical science · 2021Article
- The Pancreatic changes affecting glucose homeostasis in transfusion dependent β- thalassemia (TDT): a short review.Acta bio-medica : Atenei Parmensis · 2021Review
- Low HbA1c With Normal Hemoglobin in a Diabetes Patient Caused byFrontiers in endocrinology · 2020Article
- Review
- Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Article
- Chronic High Dose Zinc Supplementation Induces Visceral Adipose Tissue Hypertrophy without Altering Body Weight in Mice.Nutrients · 2017Article
- Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model.The Journal of nutritional biochemistry · 2017Article
- Zinc and Oxidative Stress: Current Mechanisms.Antioxidants (Basel, Switzerland) · 2017Review
- Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Up to 20% of adult patients with Thalassemia major (Thal) live with diabetes, while 30% may be zinc deficient. The objective of this study was to explore the relationship between zinc status, impaired glucose tolerance and insulin sensitivity in Thal patients. Charts from thirty subjects (16 male, 27.8 ± 9.1 years) with Thal were reviewed. Patients with low serum zinc had significantly lower fasting insulin, insulinogenic and oral disposition indexes (all p < 0.05) and elevated glucose response curve, following a standard 75 g oral load of glucose compared to those with normal serum zinc after controlling for baseline (group × time interaction p = 0.048). Longitudinal data in five patients with a decline in serum zinc over a two year follow up period (-19.0 ± 9.6 μg/dL), showed consistent increases in fasting glucose (3.6 ± 3.2 mg/dL) and insulin to glucose ratios at 120 min post glucose dose (p = 0.05). Taken together, these data suggest that the frequently present zinc deficiency in Thal patients is associated with decreased insulin secretion and reduced glucose disposal. Future zinc trials will require modeling of oral glucose tolerance test data and not simply measurement of static indices in order to understand the complexities of pancreatic function in the Thal patient.
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