ArticleMolecular oral microbiology2016
Transcriptional landscape of trans-kingdom communication between Candida albicans and Streptococcus gordonii.
Article in Molecular oral microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025Review
- Glycerol metabolism contributes to competition by oral streptococci through production of hydrogen peroxide.Journal of bacteriology · 2024Article
- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
- Pseudomonas aeruginosa increases the susceptibility of Candida albicans to amphotericin B in dual-species biofilms.The Journal of antimicrobial chemotherapy · 2023Article
- The interactions of Candida albicans with gut bacteria: a new strategy to prevent and treat invasive intestinal candidiasis.Gut pathogens · 2023Review
- First Report on the Versatile Secretome of an Environmental Isolate Acinetobacter pittii S-30.Current microbiology · 2023Article
- Biomarkers of caspofungin resistance inVirulence · 2022Article
- Article
- The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries.Microbiology spectrum · 2022Article
- The Role of Glycoside Hydrolases in S. gordonii and C. albicans Interactions.Applied and environmental microbiology · 2022Article
- Review
- [Application Progress of Dual RNA Sequencing in Microbial Research].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- Transcriptomic Responses to Coaggregation between Streptococcus gordonii and Streptococcus oralis.Applied and environmental microbiology · 2021Article
- Transcriptional response of Candida albicans to Pseudomonas aeruginosa in a polymicrobial biofilm.G3 (Bethesda, Md.) · 2021Article
- Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis.Frontiers in cellular and infection microbiology · 2021Article
- Proteomic Analyses ofFrontiers in cellular and infection microbiology · 2021Article
- The Role ofFrontiers in cellular and infection microbiology · 2021Review
- Transcriptome Analyses ofG3 (Bethesda, Md.) · 2020Article
- Bacteria ModifymSphere · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent studies have shown that the transcriptional landscape of the pleiomorphic fungus Candida albicans is highly dependent upon growth conditions. Here using a dual RNA-seq approach we identified 299 C. albicans and 72 Streptococcus gordonii genes that were either upregulated or downregulated specifically as a result of co-culturing these human oral cavity microorganisms. Seventy-five C. albicans genes involved in responses to chemical stimuli, regulation, homeostasis, protein modification and cell cycle were significantly (P ≤ 0.05) upregulated, whereas 36 genes mainly involved in transport and translation were downregulated. Upregulation of filamentation-associated TEC1 and FGR42 genes, and of ALS1 adhesin gene, concurred with previous evidence that the C. albicans yeast to hypha transition is promoted by S. gordonii. Increased expression of genes required for arginine biosynthesis in C. albicans was potentially indicative of a novel oxidative stress response. The transcriptional response of S. gordonii to C. albicans was less dramatic, with only eight S. gordonii genes significantly (P ≤ 0.05) upregulated at least two-fold (glpK, rplO, celB, rplN, rplB, rpsE, ciaR and gat). The expression patterns suggest that signals from S. gordonii cause a positive filamentation response in C. albicans, whereas S. gordonii appears to be transcriptionally less influenced by C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.