ArticlePloS one2015
Ongoing HIV Transmission and the HIV Care Continuum in North Carolina.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Characterizing long-acting injectable antiretroviral therapy eligibility and initiation at a safety net academic medical center in the southeastern United States.International journal of STD & AIDS · 2025Article
- The Magnitude and Associated Factors of Early Index Case Testing Among Adult HIV Index Cases at Debre Markos Town High Load Health Facilities 2023.AIDS research and treatment · 2025Article
- Rev-Rev Response Element Activity Selection Bias at the Human Immunodeficiency Virus Transmission Bottleneck.Open forum infectious diseases · 2023Article
- Prevalence and Evolution of Transmitted Human Immunodeficiency Virus Drug Resistance in Belgium Between 2013 and 2019.Open forum infectious diseases · 2022Article
- HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.EClinicalMedicine · 2021Article
- Trajectories of Viral Suppression in People Living With HIV Receiving Coordinated Care: Differences by Comorbidities.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Human Immunodeficiency Virus Type 1 Phylodynamics to Detect and Characterize Active Transmission Clusters in North Carolina.The Journal of infectious diseases · 2020Article
- Factors Associated With Human Immunodeficiency Virus Infections Linked in Genetic Clusters But Disconnected in Partner Tracing.Sexually transmitted diseases · 2020Article
- The North-South Divide: Substance Use Risk, Care Engagement, and Viral Suppression Among Hospitalized Human Immunodeficiency Virus-Infected Patients in 11 US Cities.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Leveraging Phylogenetics to Understand HIV Transmission and Partner Notification Networks.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Sexual risk taking and the HIV care continuum in an online sample of men who have sex with men.AIDS care · 2018Article
- A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study.The lancet. HIV · 2018Article
- Integration of Contact Tracing and Phylogenetics in an Investigation of Acute HIV Infection.Sexually transmitted diseases · 2018Article
- Genetic Cluster Analysis for HIV Prevention.Current HIV/AIDS reports · 2018Review
- Cigarette Smoking and Antiretroviral Therapy (ART) Adherence in a Sample of Heavy Drinking HIV-Infected Men Who Have Sex with Men (MSM).AIDS and behavior · 2017Article
- Clinical and public health implications of acute and early HIV detection and treatment: a scoping review.Journal of the International AIDS Society · 2017Article
- Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Continuous Retention and Viral Suppression Provide Further Insights Into the HIV Care Continuum Compared to the Cross-sectional HIV Care Cascade.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Sources of HIV infection among men having sex with men and implications for prevention.Science translational medicine · 2016Article
- The Changing Role of Disease Intervention Specialists in Modern Public Health Programs.Public health reports (Washington, D.C. : 1974)Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveHIV transmission is influenced by status awareness and receipt of care and treatment. We analyzed these attributes of named partners of persons with acute HIV infection (index AHI cases) to characterize the transmission landscape in North Carolina (NC).
designSecondary analysis of programmatic data.
methodsWe used data from the NC Screening and Tracing of Active Transmission Program (2002-2013) to determine HIV status (uninfected, AHI, or chronic HIV infection [CHI]), diagnosis status (new or previously-diagnosed), and care and treatment status (not in care, in care and not on treatment, in care and on treatment) of index AHI cases' named partners. We developed an algorithm identifying the most likely transmission source among known HIV-infected partners to estimate the proportion of transmissions arising from contact with persons at different HIV continuum stages. We conducted a complementary analysis among a subset of index AHI cases and partners with phylogenetically-linked viruses.
resultsOverall, 358 index AHI cases named 932 partners, of which 218 were found to be HIV-infected (162 (74.3%) previously-diagnosed, 11 (5.0%) new AHI, 45 (20.6%) new CHI). Most transmission events appeared attributable to previously-diagnosed partners (77.4%, 95% confidence interval 69.4-85.3%). Among these previously-diagnosed partners, 23.2% (14.0-32.3%) were reported as in care and on treatment near the index AHI case diagnosis date. In the subset study of 33 phylogenetically-linked cases and partners, 60.6% of partners were previously diagnosed (43.9-77.3%).
conclusionsA substantial proportion of HIV transmission in this setting appears attributable to contact with previously-diagnosed partners, reinforcing the need for improved engagement in care after diagnosis.
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