Evidence map›Paper›PMID 26042194›Full record

ArticleCurrent pharmacology reports2015

Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.

Lauren L Atwell, Laura M Beaver, Jackilen Shannon, David E Williams, Roderick H Dashwood, Emily Ho

Open access · bronzeAbstract read
In one paragraph

Article in Current pharmacology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauren L Atwell103 Milam Hall, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA.
Laura M Beaver103 Milam Hall, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA ; 307 Linus Pauling Science Center, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Jackilen Shannon3181 SW Sam Jackson Park Road, Mail Code CB L606, Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239, USA.
David E Williams307 Linus Pauling Science Center, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA ; 1007 Agriculture & Life Sciences Building, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.
Roderick H Dashwood2121 West Holcombe Boulevard, Center for Epigenetics & Disease Prevention, Houston, TX 77030.
Emily Ho103 Milam Hall, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA ; 307 Linus Pauling Science Center, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA ; 212 Milam Hall, Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health, Oregon State University, Corvallis, OR 97331, USA.
Oregon State University · USOregon Health & Science University · US

Funding

Transplacental Chemoprevention of Lung Tumors and LymphomasP01CA090890 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DASHWOOD, RODERICK H · 2003 to 2014
$14.2M
Dietary histone deactylase inhibitors in prostate cancer preventionR01CA122906 · NCI · OREGON STATE UNIVERSITY · PI HO, EMILY · 2007 to 2011
$2.0M
Sulforaphane: A Dietary HDAC Inhibitor and Prevention of DCIS ProgressionR21CA132236 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHANNON, JACKILEN · 2009 to 2011
$541k
NCI NIH HHS P01 CA090890NCI NIH HHS R01 CA122906NCI NIH HHS R21 CA132236
6 · The paper itself

Abstract

Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that has multiple molecular targets and anti-cancer properties. Researchers have demonstrated several chemopreventive benefits of SFN consumption, such as reductions in tumor growth, increases in cancer cell apoptosis, and disruption of signaling within tumor microenvironments both

Indexed as

breastcancerchemopreventionepigeneticsprostatesulforaphane

Identifiers

PMID26042194
PMCPMC4450146
OpenAlexW2074505131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.