ArticleFrontiers in aging neuroscience2015
The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation.Disease models & mechanisms · 2026Article
- Promoting and accelerating muscle regeneration through cell therapy in a mouse model.Journal of Taibah University Medical Sciences · 2024Article
- Interplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle stem cells.PLoS genetics · 2024Article
- Overlapping functions of SIX homeoproteins during embryonic myogenesis.PLoS genetics · 2023Article
- New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation.Biology · 2022Review
- Potential Satellite Cell-Linked Biomarkers in Aging Skeletal Muscle Tissue: Proteomics and Proteogenomics to Monitor Sarcopenia.Proteomes · 2022Review
- The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development.Life (Basel, Switzerland) · 2022Article
- Characterisation of stemness and multipotency of ovine muscle-derived stem cells from various muscle sources.Journal of anatomy · 2021Article
- Distinct Embryonic Origin and Injury Response of Resident Stem Cells in Craniofacial Muscles.Frontiers in physiology · 2021Review
- How to distinguish between different cell lineages sharing common markers using combinations of double in-situ-hybridization and immunostaining in avian embryos: CXCR4-positive mesodermal and neural crest-derived cells.Histochemistry and cell biology · 2021Article
- Generation of craniofacial myogenic progenitor cells from human induced pluripotent stem cells for skeletal muscle tissue regeneration.Biomaterials · 2020Article
- Cxcr4 and Sdf-1 are critically involved in the formation of facial and non-somitic neck muscles.Scientific reports · 2020Article
- The CXCR4/SDF-1 Axis in the Development of Facial Expression and Non-somitic Neck Muscles.Frontiers in cell and developmental biology · 2020Review
- Location, Location, Location: Signals in Muscle Specification.Journal of developmental biology · 2018Review
- Myogenic regulatory factors: The orchestrators of myogenesis after 30 years of discovery.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Extraocular Muscle Repair and Regeneration.Current ophthalmology reports · 2017Article
- Cilia-dependent GLI processing in neural crest cells is required for tongue development.Developmental biology · 2017Article
- Embracing change: striated-for-smooth muscle replacement in esophagus development.Skeletal muscle · 2016Review
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem cells may be the most promising route toward the therapy of muscle diseases such as muscular dystrophies. It is often overlooked that muscular dystrophies affect head and body skeletal muscle differently. Moreover, these muscles develop differently. Specifically, head muscle and its stem cells develop from the non-somitic head mesoderm which also has cardiac competence. To which extent head muscle stem cells retain properties of the early head mesoderm and might even be able to switch between a skeletal muscle and cardiac fate is not known. This is due to the fact that the timing and mechanisms underlying head muscle stem cell development are still obscure. Consequently, it is not clear at which time point one should compare the properties of head mesodermal cells and head muscle stem cells. To shed light on this, we traced the emergence of head muscle stem cells in the key vertebrate models for myogenesis, chicken, mouse, frog and zebrafish, using Pax7 as key marker. Our study reveals a common theme of head muscle stem cell development that is quite different from the trunk. Unlike trunk muscle stem cells, head muscle stem cells do not have a previous history of Pax7 expression, instead Pax7 expression emerges de-novo. The cells develop late, and well after the head mesoderm has committed to myogenesis. We propose that this unique mechanism of muscle stem cell development is a legacy of the evolutionary history of the chordate head mesoderm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.