ArticleFrontiers in behavioral neuroscience2015
Both the COMT Val158Met single-nucleotide polymorphism and sex-dependent differences influence response inhibition.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Individual differences in learning and decision-making: the role of COMT Val158Met polymorphism in transitive inference.Experimental brain research · 2026Article
- Sex Differences in Opioid Response Linked toJournal of clinical medicine · 2023Article
- Reward prospect affects strategic adjustments in stop signal task.Frontiers in psychology · 2023Article
- Restart errors reaction time of a two-step inhibition process account for the violation of the race model's independence in multi-effector selective stop signal task.Frontiers in human neuroscience · 2023Article
- Neuronal Activity in the Premotor Cortex of Monkeys Reflects Both Cue Salience and Motivation for Action Generation and Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- An Exploratory Analysis of the Association Between Catechol-O-Methyltransferase and Response to a Randomized Open-Label Placebo Treatment for Cancer-Related Fatigue.Frontiers in psychiatry · 2021Article
- Corticocortical Systems Underlying High-Order Motor Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- High Cervical Spinal Cord Stimulation: A One Year Follow-Up Study on Motor and Non-Motor Functions in Parkinson's Disease.Brain sciences · 2019Article
- No association ofPeerJ · 2019Article
- Selective role for the COMT polymorphism in a trans-diagnostic compulsivity phenotype.Psychological medicine · 2018Article
- Visual salience of the stop signal affects the neuronal dynamics of controlled inhibition.Scientific reports · 2018Article
- COMT and DAT1 polymorphisms moderate the indirect effect of parenting behavior on youth ADHD symptoms through neurocognitive functioning.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2018Article
- A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder.Molecular psychiatry · 2018Article
- Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Atrophic degeneration of cerebellum impairs both the reactive and the proactive control of movement in the stop signal paradigm.Experimental brain research · 2017Article
- Visual salience of the stop-signal affects movement suppression process.Experimental brain research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive and proactive controls of actions are cognitive abilities that allow one to deal with a continuously changing environment by adjusting already programmed actions. They also set forthcoming actions by evaluating the outcome of the previous ones. Earlier studies highlighted sex-related differences in the strategies and in the pattern of brain activation during cognitive tasks involving reactive and proactive control. To further identify sex-dependent characteristics in the cognitive control of actions, in this study, we have assessed whether/how differences in performance are modulated by the COMT Val158Met single-nucleotide polymorphism (SNP), a genetic factor known to influence the functionality of the dopaminergic system-in particular, at the level of the prefrontal cortex. Two groups of male and female participants were sorted according to their genotype (Val/Val, Val/Met, and Met/Met) and tested in a stop signal task, a consolidated tool for measuring executive control in experimental and clinical settings. In each group of participants, we estimated both a measure of the capacity to react to unexpected events and the ability to monitor their performance. The between-group comparison of these measures indicated a poorer ability of male individuals and Val/Val subjects in error-monitoring. These observations suggest that sex differences in inhibitory control could be influenced by the efficiency of COMT and that other sex-specific factors have to be considered. Understanding the inter-group variability of behavioral and physiological correlates of cognitive control could provide more accurate diagnostic tools for predicting the incidence and/or the development of pathologies, like ADHD, or deviant behaviors, such as drug or alcohol abuse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.