ArticleFrontiers in cellular neuroscience2015
Ontogeny of kainate-induced gamma oscillations in the rat CA3 hippocampus in vitro.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases-an update.Acta pharmacologica Sinica · 2025Review
- Lactate Transport via Glial MCT1 and Neuronal MCT2 Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose.Journal of neurochemistry · 2025Article
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
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- Mediation of Sinusoidal Network Oscillations in the Locus Coeruleus of Newborn Rat Slices by Pharmacologically Distinct AMPA and KA Receptors.Brain sciences · 2022Article
- Autocrine Neuromodulation and Network Activity Patterns in the Locus Coeruleus of Newborn Rat Slices.Brain sciences · 2022Article
- Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery.IEEE transactions on bio-medical engineering · 2019Article
- In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick.The European journal of neuroscience · 2018Article
- Metabolic modulation of neuronal gamma-band oscillations.Pflugers Archiv : European journal of physiology · 2018Article
- Article
- Transcriptional dysregulation causes altered modulation of inhibition by haloperidol.Neuropharmacology · 2016Article
- Sensory feedback synchronizes motor and sensory neuronal networks in the neonatal rat spinal cord.Nature communications · 2016Article
- Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity.Frontiers in cellular neuroscience · 2016Article
- Energy and Potassium Ion Homeostasis during Gamma Oscillations.Frontiers in molecular neuroscience · 2016Review
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Authors and funding
5 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
GABAergic inhibition, which is instrumental in the generation of hippocampal gamma oscillations, undergoes significant changes during development. However, the development of hippocampal gamma oscillations remains largely unknown. Here, we explored the developmental features of kainate-induced oscillations (KA-Os) in CA3 region of rat hippocampal slices. Up to postnatal day P5, the bath application of kainate failed to evoke any detectable oscillations. KA-Os emerged by the end of the first postnatal week; these were initially weak, slow (20-25 Hz, beta range) and were poorly synchronized with CA3 units and synaptic currents. Local field potential (LFP) power, synchronization of units and frequency of KA-Os increased during the second postnatal week to attain gamma (30-40 Hz) frequency by P15-21. Both beta and gamma KA-Os are characterized by alternating sinks and sources in the pyramidal cell layer, likely generated by summation of the action potential-associated currents and GABAergic synaptic currents, respectively. Blockade of GABA(A) receptors with gabazine completely suppressed KA-Os at all ages indicating that GABAergic mechanisms are instrumental in their generation. Bumetanide, a NKCC1 chloride co-transporter antagonist which renders GABAergic responses inhibitory in the immature hippocampal neurons, failed to induce KA-Os at P2-4 indicating that the absence of KA-Os in neonates is not due to depolarizing actions of GABA. The linear developmental profile, electrographic features and pharmacological properties indicate that CA3 hippocampal beta and gamma KA-Os are fundamentally similar in their generative mechanisms and their delayed onset and developmental changes likely reflect the development of perisomatic GABAergic inhibition.
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