ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Coupled changes in brain white matter microstructure and fluid intelligence in later life.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Trial
- Oligodendrocyte dysfunction in human age-related cognitive decline.Nature medicine · 2026Article
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization.Molecular psychiatry · 2025Article
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- Exploring the relationship between larmor-frequency electrical conductivity, diffusivity, and tissue volume in the aging brain.Quantitative imaging in medicine and surgery · 2025Article
- Lessons we learned from the Lothian Birth Cohorts of 1921 and 1936.Genomic psychiatry : advancing science from genes to society · 2025Article
- Choir singing is associated with enhanced structural connectivity across the adult lifespan.Human brain mapping · 2024Article
- The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Compensatory brain activity pattern is not present in older adults during the n-back task performance-Findings based on EEG frequency analysis.Frontiers in psychology · 2024Article
- Estimating the effect of physical activity on cognitive function within the UK Biobank cohort.International journal of epidemiology · 2023Article
- Young versus older subject diffusion magnetic resonance imaging data for virtual white matter lesion tractography.Human brain mapping · 2023Article
- Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936.International journal of geriatric psychiatry · 2023Article
- Article
- Within-person changes in the aging white matter microstructure and their modifiers: A meta-analysis and systematic review of longitudinal diffusion tensor imaging studies.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Genetic variation, brain, and intelligence differences.Molecular psychiatry · 2022Review
- Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936.Human brain mapping · 2021Article
- Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n = 17,706).Molecular psychiatry · 2021Article
- Estimates of brain age for gray matter and white matter in younger and older adults: Insights into human intelligence.Brain research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Understanding aging-related cognitive decline is of growing importance in aging societies, but relatively little is known about its neural substrates. Measures of white matter microstructure are known to correlate cross-sectionally with cognitive ability measures, but only a few small studies have tested for longitudinal relations among these variables. We tested whether there were coupled changes in brain white matter microstructure indexed by fractional anisotropy (FA) and three broad cognitive domains (fluid intelligence, processing speed, and memory) in a large cohort of human participants with longitudinal diffusion tensor MRI and detailed cognitive data taken at ages 73 years (n = 731) and 76 years (n = 488). Longitudinal changes in white matter microstructure were coupled with changes in fluid intelligence, but not with processing speed or memory. Individuals with higher baseline white matter FA showed less subsequent decline in processing speed. Our results provide evidence for a longitudinal link between changes in white matter microstructure and aging-related cognitive decline during the eighth decade of life. They are consistent with theoretical perspectives positing that a corticocortical "disconnection" partly explains cognitive aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.