ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Subcortical glutamate mediates the reduction of short-range functional connectivity with age in a developmental cohort.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Neurometabolite differences in Autism as assessed with Magnetic Resonance Spectroscopy: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Pooled it
- Age- and alcohol-related differences in adolescent neurometabolite levels.Alcohol, clinical & experimental research · 2026Article
- IronDeficiency Across Neurodevelopmental Disorders: Comparative Insights from ADHD and Autism Spectrum Disorder.Children (Basel, Switzerland) · 2026Review
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neurochemical changes in GABA+, Glx, and the excitatory/inhibitory ratio in the calcarine cortex with healthy aging.NeuroImage · 2025Article
- Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling.Science advances · 2025Article
- Adolescent maturation of dorsolateral prefrontal cortex glutamate:GABA and cognitive function is supported by dopamine-related neurobiology.Molecular psychiatry · 2025Article
- "Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.Translational psychiatry · 2025Article
- Altered markers of brain metabolism and excitability are associated with executive functioning in young children exposed to alcohol in utero.Metabolic brain disease · 2024Article
- In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- In-vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth.bioRxiv : the preprint server for biology · 2024Article
- The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- GABA levels decline with age: A longitudinal study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Longitudinal change in mismatch negativity (MMN) but not in gamma-band auditory steady-state response (ASSR) is associated with psychological difficulties in adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- Development of frontal GABA and glutamate supports excitation/inhibition balance from adolescence into adulthood.Progress in neurobiology · 2022Article
- The macromolecular MR spectrum does not change with healthy aging.Magnetic resonance in medicine · 2022Article
- A developmental reduction of the excitation:inhibition ratio in association cortex during adolescence.Science advances · 2022Article
- Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.Neuron · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marked changes in brain physiology and structure take place between childhood and adulthood, including changes in functional connectivity and changes in the balance between main excitatory and inhibitory neurotransmitters glutamate (Glu) and GABA. The balance of these neurotransmitters is thought to underlie neural activity in general and functional connectivity networks in particular, but so far no studies have investigated the relationship between human development related differences in these neurotransmitters and concomitant changes in functional connectivity. GABA+/H2O and Glu/H2O levels were acquired in a group of healthy children, adolescents, and adults in a subcortical (basal ganglia) region, as well as in a frontal region in adolescents and adults. Our results showed higher GABA+/Glu with age in both the subcortical and the frontal voxel, which were differentially associated with significantly lower Glu/H2O with age in the subcortical voxel and by significantly higher GABA+/H2O with age in the frontal voxel. Using a seed-to-voxel analysis, we were further able to show that functional connectivity between the putamen (seed) and other subcortical structures was lower with age. Lower subcortical Glu/H2O with age mediated the lower connectivity in the dorsal putamen. Based on these results, and the potential role of Glu in synaptic pruning, we suggest that lower Glu mediates a reduction of local connectivity during human development.
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