Evidence map›Paper›PMID 26041875›Full record

ArticleThe Journal of general virology2015

Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure.

Stephanie Pfaender, Stephanie Walter, Daniel Todt, Patrick Behrendt, Juliane Doerrbecker, Benno Wölk, Michael Engelmann, Ute Gravemann, Axel Seltsam, Joerg Steinmann and 6 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Viral Diseases that Affect Donkeys and Mules.Animals : an open access journal from MDPI · 2020
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Stephanie PfaenderInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Stephanie WalterInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Daniel TodtInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Patrick BehrendtInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Juliane DoerrbeckerInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Benno WölkInstitute of Virology, Hannover Medical School, Hannover, Germany.
Michael EngelmannInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Ute GravemannGerman Red Cross Blood Service NSTOB, Institute Springe, Springe, Germany.
Axel SeltsamGerman Red Cross Blood Service NSTOB, Institute Springe, Springe, Germany.
Joerg SteinmannInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Peter D BurbeloDental Clinical Research Core, National Institute of Dental Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Frank KlawonnBioinformatics and Statistics Research Group, Department of Cellular Proteomics, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.
Karsten FeigeClinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany.
Thomas PietschmannInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Jessika-M V CavalleriClinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany.
Eike SteinmannInstitute of Experimental Virology, Twincore - Centre of Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Center for Experimental and Clinical Infection Research · DEGerman Red Cross · DEUniversity of Veterinary Medicine Hannover, Foundation · DEMedizinische Hochschule Hannover · DENational Institute of Dental and Craniofacial Research · USOstfalia University of Applied Sciences · DEUniversity of Duisburg-Essen · DE

Funding

European Research Council 281473Intramural NIH HHS
6 · The paper itself

Abstract

The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.

Indexed as

AdultAgricultural Workers' DiseasesAnimalsFemaleHepacivirusHepatitis CHorse DiseasesHorsesHumansMaleMiddle AgedOccupational ExposurePhylogenyZoonoses

Identifiers

PMID26041875
PMCPMC4857452
OpenAlexW1916801543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.