Evidence map›Paper›PMID 26041787›Full record

ArticlePlant physiology2015

Ethylene-Mediated Regulation of A2-Type CYCLINs Modulates Hyponastic Growth in Arabidopsis.

Joanna K Polko, Jop A van Rooij, Steffen Vanneste, Ronald Pierik, Ankie M H Ammerlaan, Marleen H Vergeer-van Eijk, Fionn McLoughlin, Kerstin Gühl, Gert Van Isterdael, Laurentius A C J Voesenek and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. The Pivotal Role of Ethylene in Plant Growth.Trends in plant science · 2018
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Focus on Ethylene.Plant physiology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Joanna K PolkoPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Jop A van RooijPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Steffen VannestePlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Ronald PierikPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Ankie M H AmmerlaanPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Marleen H Vergeer-van EijkPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Fionn McLoughlinPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Kerstin GühlPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Gert Van IsterdaelPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Laurentius A C J VoesenekPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Frank F MillenaarPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Tom BeeckmanPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Anton J M PeetersPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Athanasius F M MaréePlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.).
Martijn van ZantenPlant Ecophysiology, Institute of Environmental Biology (J.K.P., R.P., A.M.H.A., M.H.V.-v.E., F.M., K.G., L.A.C.J.V., F.F.M., A.J.M.P., M.v.Z.), and Theoretical Biology and Bioinformatics (J.A.v.R.), Utrecht University, 3584 CH Utrecht, The Netherlands;Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom (J.A.v.R., A.F.M.M.);Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.); andDepartment of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (S.V., G.V.I., T.B.) m.vanzanten@uu.nl.
Ghent University · BENorwich Research Park · GBVIB-UGent Center for Plant Systems Biology · BE

Funding

Biotechnology and Biological Sciences Research Council BB/J004553/1Biotechnology and Biological Sciences Research Council BBS/E/J/000C0645
6 · The paper itself

Abstract

Upward leaf movement (hyponastic growth) is frequently observed in response to changing environmental conditions and can be induced by the phytohormone ethylene. Hyponasty results from differential growth (i.e. enhanced cell elongation at the proximal abaxial side of the petiole relative to the adaxial side). Here, we characterize Enhanced Hyponasty-d, an activation-tagged Arabidopsis (Arabidopsis thaliana) line with exaggerated hyponasty. This phenotype is associated with overexpression of the mitotic cyclin CYCLINA2;1 (CYCA2;1), which hints at a role for cell divisions in regulating hyponasty. Indeed, mathematical analysis suggested that the observed changes in abaxial cell elongation rates during ethylene treatment should result in a larger hyponastic amplitude than observed, unless a decrease in cell proliferation rate at the proximal abaxial side of the petiole relative to the adaxial side was implemented. Our model predicts that when this differential proliferation mechanism is disrupted by either ectopic overexpression or mutation of CYCA2;1, the hyponastic growth response becomes exaggerated. This is in accordance with experimental observations on CYCA2;1 overexpression lines and cyca2;1 knockouts. We therefore propose a bipartite mechanism controlling leaf movement: ethylene induces longitudinal cell expansion in the abaxial petiole epidermis to induce hyponasty and simultaneously affects its amplitude by controlling cell proliferation through CYCA2;1. Further corroborating the model, we found that ethylene treatment results in transcriptional down-regulation of A2-type CYCLINs and propose that this, and possibly other regulatory mechanisms affecting CYCA2;1, may contribute to this attenuation of hyponastic growth.

Indexed as

Gene Expression Regulation, PlantArabidopsisCell ProliferationCyclin A2Down-RegulationEthylenesHypocotylLightModels, BiologicalPlant Growth RegulatorsPlant LeavesCyclin A2ethyleneEthylenesPlant Growth Regulators

Identifiers

PMID26041787
PMCPMC4577382
OpenAlexW2144086774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.