ArticleMolecular neurobiology2016
Rescue of Brain Function Using Tunneling Nanotubes Between Neural Stem Cells and Brain Microvascular Endothelial Cells.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- Multiple sevoflurane exposures in early development lead to long-term vascular abnormalities in the hippocampus.Cell biology and toxicology · 2026Article
- Mechanisms of Mitochondrial Transfer Through TNTs: From Organelle Dynamics to Cellular Crosstalk.International journal of molecular sciences · 2025Review
- Navigation Between Alzheimer's Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology-Genetics and Neuroinflammation.International journal of molecular sciences · 2025Review
- Neural stem cell-derived exosomes regulate cell proliferation, migration, and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia.Animal models and experimental medicine · 2024Article
- Review
- Secretome and Tunneling Nanotubes: A Multilevel Network for Long Range Intercellular Communication between Endothelial Cells and Distant Cells.International journal of molecular sciences · 2021Review
- Opportunities and Challenges in Tunneling Nanotubes Research: How Far from Clinical Application?International journal of molecular sciences · 2021Review
- ELAVL1 Role in Cell Fusion and Tunneling Membrane Nanotube Formations with Implication to Treat Glioma Heterogeneity.Cancers · 2020Review
- Exosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury.Neural plasticity · 2020Article
- Are cell membrane nanotubes the ancestors of the nervous system?European biophysics journal : EBJ · 2019Review
- Perspective on nanochannels as cellular mediators in different disease conditions.Cell communication and signaling : CCS · 2018Review
- Protective effects of primary neural stem cell treatment in ischemic stroke models.Experimental and therapeutic medicine · 2018Article
- Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin.Scientific reports · 2018Article
- Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.Frontiers in molecular neuroscience · 2017Review
- Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links.Frontiers in molecular biosciences · 2017Review
- Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis.Theoretical biology & medical modelling · 2016Review
- Proteostasis and Diseases of the Motor Unit.Frontiers in molecular neuroscience · 2016Article
- Proteostasis and aging.Nature medicine · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NSCs and brain microvascular endothelial cells (BMECs) and, particularly, the control of TNT formation could influence the rescue function of stem cells. In an attempt to mimic the cellular microenvironment in vitro, a co-culture system consisting of terminally differentiated BMECs from mice in a distressed state and NSCs was constructed. Additionally, engraftment experiments with infarcted mouse brains revealed that control of TNT formation influenced the effects of stem cell transplantation in vivo. In conclusion, our findings provide the first evidence that TNTs exist between NSCs and BMECs and that regulation of TNT formation alters cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.