ArticleJournal of neurology2015
Eye-tracking controlled cognitive function tests in patients with amyotrophic lateral sclerosis: a controlled proof-of-principle study.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness of eye tracking in the diagnosis of cognitive disorders: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Visual Attention in Real Classrooms: A Study with Eye-Tracking in Urban and Rural Schools of Chile.Journal of eye movement research · 2026Article
- Update on recent advances in amyotrophic lateral sclerosis.Journal of neurology · 2024Review
- ETMT: A Tool for Eye-Tracking-Based Trail-Making Test to Detect Cognitive Impairment.Sensors (Basel, Switzerland) · 2023Article
- Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders.Neurology · 2021Article
- New technologies and Amyotrophic Lateral Sclerosis - Which step forward rushed by the COVID-19 pandemic?Journal of the neurological sciences · 2020Review
- Eye tracking metrics to screen and assess cognitive impairment in patients with neurological disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- An ERP-based BCI with peripheral stimuli: validation with ALS patients.Cognitive neurodynamics · 2020Article
- Ethical Principles in Patient-Centered Medical Care to Support Quality of Life in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2019Review
- Screening for Cognitive Function in Complete Immobility Using Brain-Machine Interfaces: A Proof of Principle Study.Frontiers in neuroscience · 2018Article
- Communication Matters-Pitfalls and Promise of Hightech Communication Devices in Palliative Care of Severely Physically Disabled Patients With Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
- The Arrows and Colors Cognitive Test (ACCT): A new verbal-motor free cognitive measure for executive functions in ALS.PloS one · 2018Article
- An eye-tracker controlled cognitive battery: overcoming verbal-motor limitations in ALS.Journal of neurology · 2017Article
- An eye-tracking controlled neuropsychological battery for cognitive assessment in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis.Journal of visualized experiments : JoVE · 2016Article
- Recent advances in amyotrophic lateral sclerosis.Journal of neurology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyotrophic lateral sclerosis (ALS) primarily affects motor and speech abilities. In addition, cognitive functions are impaired in a subset of patients. There is a need to establish an eye movement-based method of neuropsychological assessment suitable for severely physically impaired patients with ALS. Forty-eight ALS patients and thirty-two healthy controls matched for age, sex and education performed a hand and speech motor-free version of the Raven's coloured progressive matrices (CPM) and the D2-test which had been especially adapted for eye-tracking control. Data were compared to a classical motor-dependent paper-pencil version. The association of parameters of the eye-tracking and the paper-pencil version of the tests and the differences between and within groups were studied. Subjects presented similar results in the eye-tracking and the corresponding paper-pencil versions of the CPM and D2-test: a correlation between performance accuracy for the CPM was observed for ALS patients (p < 0.001) and controls (p < 0.001) and in the D2-test for controls (p = 0.048), whereas this correlation did not reach statistical significance for ALS patients (p = 0.096). ALS patients performed worse in the CPM than controls in the eye-tracking (p = 0.053) and the paper-pencil version (p = 0.042). Most importantly, eye-tracking versions of the CPM (p < 0.001) and the D2-test (p = 0.024) reliably distinguished between more and less cognitively impaired patients. Eye-tracking-based neuropsychological testing is a promising approach for assessing cognitive deficits in patients who are unable to speak or write such as patients with severe ALS.
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Registered trials
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