ArticleBMJ open2015
Do patterns of mental healthcare predict treatment failure in young people with schizophrenia? Evidence from an Italian population-based cohort study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Continuity of Care and Patient Outcomes in Populations With Schizophrenia: A Systematic Review.Psychiatric services (Washington, D.C.) · 2026Pooled it
- Assessing the quality of the care offer for people with personality disorders in Italy: the QUADIM project. A multicentre research based on the database of use of Mental Health services.International journal of mental health systems · 2023Article
- Capturing the variety of clinical pathways in patients with schizophrenic disorders through state sequences analysis.BMC medical research methodology · 2023Article
- The quality of mental health care for people with bipolar disorders in the Italian mental health system: the QUADIM project.BMC psychiatry · 2023Article
- Assessment and Monitoring of the Quality of Clinical Pathways in Patients with Depressive Disorders: Results from a Multiregional Italian Investigation on Mental Health Care Quality (the QUADIM Project).Journal of clinical medicine · 2023Article
- Does the mental health system provide effective coverage to people with schizophrenic disorder? A self-controlled case series study in Italy.Social psychiatry and psychiatric epidemiology · 2022Article
- The quality of mental health care delivered to patients with schizophrenia and related disorders in the Italian mental health system. The QUADIM project: a multi-regional Italian investigation based on healthcare utilisation databases.Epidemiology and psychiatric sciences · 2022Article
- From contact coverage to effective coverage of community care for patients with severe mental disorders: A real-world investigation from Italy.Frontiers in psychiatry · 2022Article
- Structured Evaluation of Rehabilitation Programs Outcomes in Psychiatry: Application of a Recovery-Centered Model.The Psychiatric quarterly · 2021Observational
- The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?Drug safety · 2019Review
- Integrated Programs for Early Recognition of Severe Mental Disorders: Recommendations From an Italian Multicenter Project.Frontiers in psychiatry · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLittle is known about the practice of predicting community-based care effectiveness of patients affected by schizophrenic disorders. We assessed predictors of treatment failure in a large sample of young people affected by schizophrenia.
methodsA cohort of 556 patients aged 18-35 years who were originally diagnosed with schizophrenia during 2005-2009 in a Mental Health Service (MHS) of the Italian Lombardy Region was identified. Intensity of mental healthcare received during the first year after index visit (exposure) was measured by patients' regularity in MHS attendance and the length of time covered with antipsychotic drug therapy. Patients were followed from index visit until 2012 for identifying hospital admission for mental disorder (outcome). A proportional hazards model was fitted to estimate the HR and 95% CIs for the exposure-outcome association, after adjusting for several covariates. A set of sensitivity analyses were performed in order to account for sources of systematic uncertainty.
resultsDuring follow-up, 144 cohort members experienced the outcome. Compared with patients on low coverage with antipsychotic drugs (≤ 4 months), those on intermediate (5-8 months) and high (≥ 9 months) coverage, had HRs (95% CI) of 0.94 (0.64 to 1.40) and 0.69 (0.48 to 0.98), respectively. There was no evidence that regular attendance at the MHS affected the outcome.
conclusionsPatients in the early phase of schizophrenia and their families should be cautioned about the possible consequences of poor antipsychotic adherence. Physicians and decision makers should increase their contribution towards improving mental healthcare.
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