ArticleJournal of the American Medical Informatics Association : JAMIA2015
Birth month affects lifetime disease risk: a phenome-wide method.
Article in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Associations between month/season of birth and health outcomes: an umbrella review of systematic reviews and meta-analyses.Journal of global health · 2026Pooled it
- Female Reproductive Performance and Maternal Birth Month: A Comprehensive Meta-Analysis Exploring Multiple Seasonal Mechanisms.Scientific reports · 2020Pooled it
- Attention deficit hyperactivity disorder late birthdate effect common in both high and low prescribing international jurisdictions: a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2019Pooled it
- Replicating Cardiovascular Condition-Birth Month Associations.Scientific reports · 2016Trial
- Toward the promotion of One Health - Part II: Interdisciplinary research cooperation between digital transformation and exposome.The journal of physiological sciences : JPS · 2026Review
- Early-life exposure to ambient temperature and polycystic ovary syndrome: a nationwide cohort study.International journal of epidemiology · 2026Article
- Exploring Repro-Timing Harm and Benefit.Bioethics · 2026Article
- Global trends in human birth and death seasonality reveal climate-related shifts in reproductive timing.bioRxiv : the preprint server for biology · 2026Article
- Season of birth and variations in male reproductive health: A population-based cohort study.Andrology · 2026Article
- No evidence for an association between in utero Ramadan exposure and mean arterial pressure and random blood glucose in adulthood: evidence from SEACO in Malaysia.Journal of nutritional science · 2025Article
- Uncovering Important Diagnostic Features for Alzheimer's, Parkinson's and Other Dementias Using Interpretable Association Mining Methods.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Investigating the association between season of birth and symptoms of depression and anxiety in adults.PLOS mental health · 2025Article
- Are season of birth, climate, and parental age predictors of adult temperament, character, anhedonia, suicidality, and self-harm?Frontiers in psychiatry · 2025Article
- Determining the Importance of Clinical Modalities for NeuroDegenerative Disorders and Risk of Patient Injury Using Machine Learning and Survival Analysis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- Investigating the Influence of Birth Month on the Incidence of Burning Mouth Syndrome.Oral diseases · 2024Article
- Seasonal Variations in Birth Patterns in Greece: A Comprehensive Analysis of National Data From 1956 to 2022.Cureus · 2024Article
- Nontraditional models as research tools: the road not taken.Trends in molecular medicine · 2024Review
- Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland.Clinical and translational allergy · 2024Article
- Optimal timing of influenza vaccination in young children: population based cohort study.BMJ (Clinical research ed.) · 2024Article
- An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank.PloS one · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveAn individual's birth month has a significant impact on the diseases they develop during their lifetime. Previous studies reveal relationships between birth month and several diseases including atherothrombosis, asthma, attention deficit hyperactivity disorder, and myopia, leaving most diseases completely unexplored. This retrospective population study systematically explores the relationship between seasonal affects at birth and lifetime disease risk for 1688 conditions.
methodsWe developed a hypothesis-free method that minimizes publication and disease selection biases by systematically investigating disease-birth month patterns across all conditions. Our dataset includes 1 749 400 individuals with records at New York-Presbyterian/Columbia University Medical Center born between 1900 and 2000 inclusive. We modeled associations between birth month and 1688 diseases using logistic regression. Significance was tested using a chi-squared test with multiplicity correction.
resultsWe found 55 diseases that were significantly dependent on birth month. Of these 19 were previously reported in the literature (P < .001), 20 were for conditions with close relationships to those reported, and 16 were previously unreported. We found distinct incidence patterns across disease categories.
conclusionsLifetime disease risk is affected by birth month. Seasonally dependent early developmental mechanisms may play a role in increasing lifetime risk of disease.
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Registered trials
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