ArticlePsychopharmacology2015
Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model.Addiction (Abingdon, England) · 2017Pooled it
- Is Abstinence from Alcohol and Smoking Associated with Less Anxiety and Depressive Symptoms Among People with HIV?AIDS and behavior · 2024Trial
- Navigating Defense Mechanisms in Alcohol Use Disorders: Implications for Psychiatric Mental Health Nursing.Advances in experimental medicine and biology · 2026Review
- The absence of association between anorexia nervosa and smoking: converging evidence across two studies.European child & adolescent psychiatry · 2023Article
- Pathways to the persistence of drug use despite its adverse consequences.Molecular psychiatry · 2023Review
- Quantifying value-based determinants of drug and non-drug decision dynamics.Psychopharmacology · 2021Article
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
- Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders.Psychopharmacology · 2020Article
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Goal-Directed and Habitual Control in Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Negative Mood Induction Increases Choice of Heroin Versus Food Pictures in Opiate-Dependent Individuals: Correlation With Self-Medication Coping Motives and Subjective Reactivity.Frontiers in psychiatry · 2019Article
- Negative mood-induced alcohol-seeking is greater in young adults who report depression symptoms, drinking to cope, and subjective reactivity.Experimental and clinical psychopharmacology · 2018Article
- Cancer Patients Enrolled in a Smoking Cessation Clinical Trial: Characteristics and Correlates of Smoking Rate and Nicotine Dependence.Journal of addiction · 2018Article
- Depressive statements prime goal-directed alcohol-seeking in individuals who report drinking to cope with negative affect.Psychopharmacology · 2018Article
- Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior.Drug and alcohol dependence · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundTwo theories explain how negative mood primes smoking behaviour. The stimulus-response (S-R) account argues that in the negative mood state, smoking is experienced as more reinforcing, establishing a direct (automatic) association between the negative mood state and smoking behaviour. By contrast, the incentive learning account argues that in the negative mood state smoking is expected to be more reinforcing, which integrates with instrumental knowledge of the response required to produce that outcome.
objectivesOne differential prediction is that whereas the incentive learning account anticipates that negative mood induction could augment a novel tobacco-seeking response in an extinction test, the S-R account could not explain this effect because the extinction test prevents S-R learning by omitting experience of the reinforcer.
methodsTo test this, overnight-deprived daily smokers (n = 44) acquired two instrumental responses for tobacco and chocolate points, respectively, before smoking to satiety. Half then received negative mood induction to raise the expected value of tobacco, opposing satiety, whilst the remainder received positive mood induction. Finally, a choice between tobacco and chocolate was measured in extinction to test whether negative mood could augment tobacco choice, opposing satiety, in the absence of direct experience of tobacco reinforcement.
resultsNegative mood induction not only abolished the devaluation of tobacco choice, but participants with a significant increase in negative mood increased their tobacco choice in extinction, despite satiety.
conclusionsThese findings suggest that negative mood augments drug-seeking by raising the expected value of the drug through incentive learning, rather than through automatic S-R control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.