Evidence map›Paper›PMID 26041277›Full record

ArticleAbdominal imaging2015

Adrenal (131)I-6β-iodomethylnorcholesterol scintigraphy in choosing the side for adrenalectomy in bilateral adrenal tumors with subclinical hypercortisolemia.

Lucyna Papierska, Jarosław Ćwikła, Michał Rabijewski, Piotr Glinicki, Maciej Otto, Anna Kasperlik-Załuska

Registry-linked trialAbstract read
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In one paragraph

Article in Abdominal imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05255900 (Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05255900 completednot on this mapstarted 2022, after this paper: background citation

Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism

TypeobservationalSponsorIstituto Auxologico ItalianoRan2022 to 2025Enrolled20ConditionsHypercortisolismArmsMetyrapone Capsules
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Development of Fluorinated NP-59: A Revival of Cholesterol Use Imaging with PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucyna PapierskaDepartment of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland. lucyferysia@wp.pl.
Jarosław ĆwikłaDepartment of Radiology, The Faculty of Medical Sciences, University of Warmia and Mazury, Uniwersytet Warmińsko-Mazurski, ul. Warszawska 30, 10-082, Olsztyn, Poland.
Michał RabijewskiDepartment of Internal Diseases, Diabetology and Endocrinology, Medical University of Warsaw, Mazowiecki Szpital Bródnowski, ul. Kondratowicza 8, 03-242, Warsaw, Poland.
Piotr GlinickiDepartment of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland.
Maciej OttoDepartment of General, Vascular and Transplant Surgery, Medical University of Warsaw, CSKUM, ul. Banacha 1a, 02-097, Warsaw, Poland.
Anna Kasperlik-ZałuskaDepartment of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdrenal scintigraphy with 131I-6β-iodomethylnorcholesterol is considered by several authors the gold standard for assessing tumors with subclinical hypercortisolemia. However, most of the described series consist mainly of cases with unilateral lesions. The aim of our study was to assess whether scintigraphy is useful in choosing the adrenalectomy side in the case of bilateral adrenal tumors with subclinical hypercortisolemia.

methodsThe study focused on 15 consecutive patients with benign bilateral adrenal tumors and subclinical hypercortisolemia. The scintigraphy with 131I-6β-iodomethylnorcholesterol was performed. Fourteen patients underwent unilateral adrenalectomy; the gland with predominant uptake on scintigraphy was removed. Cortisol and ACTH concentrations were measured one and six months after surgery. Post-dexamethasone cortisolemia was assessed six months after surgery. To date, the patients have been under postoperative observation for 1-4 years.

resultsFour patients showed unilateral uptake of radiotracer, and nine patients showed predominant accumulation of radiotracer in one of the adrenal glands. The smaller tumor was predominant in 2 cases. Percentage of activity on the predominant side correlates positively with the difference between tumors' diameters. Unilateral uptake of radiotracer predicts long-lasting postoperative insufficiency of the second adrenal gland. Excision of predominating tumor led to cessation of hypercortisolemia in all patients.

conclusionsThe corticoadrenal scintigraphy is useful in choosing the side for operation in the case of bilateral adrenal tumors with subclinical hypercortisolemia.

Indexed as

AdosterolAdrenalectomyIodine RadioisotopesAdrenal Gland NeoplasmsAdrenal GlandsAgedCushing SyndromeFemaleFollow-Up StudiesHumansMaleMiddle AgedRadionuclide ImagingAdosterolIodine RadioisotopesAdrenal scintigraphyBilateral adrenal tumorsIodomethylnorcholesterol scintigraphySubclinical hypercortisolemia

Identifiers

PMID26041277
PMCPMC4584114

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Registered trials

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