ArticleNature communications2015
Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
258 citing papers in PubMed, 1,422 citations in OpenAlex.
- Semiautomated Synthesis and Interactive Visualization of Zeolitic Imidazolate Framework-Based Biocomposites.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Article
- Metal-Organic Framework-Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Facile synthesis of amorphous coordinated metal-drug frameworks for cancer immunotherapy.Materials today. Bio · 2026Article
- Stimulus-Responsive MOF-Hydrogel Composites for Sensing Applications.ChemPlusChem · 2026Review
- Bioenzymatic Approach to Cholesterol Detection Using Cholesterol Oxidase-Immobilized Copper-Incorporated Zeolitic Imidazolate Framework-8.ChemPlusChem · 2026Article
- Metal-Organic Framework-Gated Biocatalysis Enables Triggered Depolymerization of Melt-Processed Polyesters.Angewandte Chemie (International ed. in English) · 2026Article
- Direct Synthesis of High-Valence Protein@UiO-66 Composites: Linking Crystallization Pathways to Protein Encapsulation.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Metal-Organic Framework-Immobilized Mycotoxin-Degrading Enzymes: Interfaces, Host Design, and Food/Feed Applications.Toxins · 2026Review
- Biomacromolecule-MOF Composites for Intracellular Delivery: From Empirical Construction to Rational Design and AI-Assisted Screening.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Sonoenzymatically Triggered Cascading Degradation of Bioresorbable Materials for On-Demand Transient Triboelectric Implants.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Metal-Organic Frameworks in Food Biotechnology: Opportunities, Challenges, and Future Perspectives for Probiotic Delivery, Precision Fermentation, and Circular Food Systems.Nanomaterials (Basel, Switzerland) · 2026Review
- RapidChemical science · 2026Article
- Surface Functionalization of Zeolitic Imidazolate Framework-8 Nanoparticles with Accessible Groups for Covalent Conjugation.Inorganic chemistry · 2026Article
- Research progress in immobilized nanozymes based on hybrid nanoflowers, MOFs and nanogels.Mikrochimica acta · 2026Review
- Hierarchically Engineered Multi-Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Recent advances in stimuli-responsive nanomaterials for the treatment of acute kidney injury.Journal of nanobiotechnology · 2026Review
- Zr-based metal-organic frameworks for colorimetric sensing applications.RSC applied interfaces · 2026Review
- Regulation of Microenvironments of Hydrogen-Bonded Organic Frameworks for Enhanced Enzyme Activity of Phosphotriesterase.Molecules (Basel, Switzerland) · 2026Article
- Surface Engineering on Transition Metal Dichalcogenides: In Situ Encapsulation of Metal-Organic Frameworks for Highly Humidity-Resistant Gas Sensing at Room Temperature.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
198 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancing the robustness of functional biomacromolecules is a critical challenge in biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical processing and biostorage. Here we report a novel method, inspired by natural biomineralization processes, which provides unprecedented protection of biomacromolecules by encapsulating them within a class of porous materials termed metal-organic frameworks. We show that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules. The resulting biocomposite is stable under conditions that would normally decompose many biological macromolecules. For example, urease and horseradish peroxidase protected within a metal-organic framework shell are found to retain bioactivity after being treated at 80 °C and boiled in dimethylformamide (153 °C), respectively. This rapid, low-cost biomimetic mineralization process gives rise to new possibilities for the exploitation of biomacromolecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.