Evidence map›Paper›PMID 26041050›Full record

ArticleGlia2015

Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitis.

James R Lokensgard, Scott J Schachtele, Manohar B Mutnal, Wen S Sheng, Sujata Prasad, Shuxian Hu

Abstract read
In one paragraph

Article in Glia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024
    Review
  6. Keeping T cell memories in mind.Trends in immunology · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Glial Cell Expression of PD-L1.International journal of molecular sciences · 2019
    Review
  14. CD4Journal of the American Heart Association · 2019
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

James R LokensgardCenter for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Scott J SchachteleCenter for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Manohar B MutnalCenter for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Wen S ShengCenter for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Sujata PrasadCenter for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Shuxian HuCenter for Infectious Diseases and Microbiology Translational Research, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · US

Funding

Role of B-cells and CNS antibodies in modulating chronic microglial activationR01NS038836 · NINDS · UNIVERSITY OF MINNESOTA · PI LOKENSGARD, JAMES R · 2000 to 2022
$7.3M
T lymphocyte-induced glial activation during CNS immune reconstitution diseaseR01MH066703 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOKENSGARD, JAMES R · 2003 to 2023
$6.9M
NIMH NIH HHS R01 MH066703NINDS NIH HHS R01 NS038836
6 · The paper itself

Abstract

Long-term, persistent central nervous system inflammation is commonly seen following brain infection. Using a murine model of viral encephalitis (murine cytomegalovirus, MCMV) we have previously shown that post-encephalitic brains are maintained in an inflammatory state consisting of glial cell reactivity, retention of brain-infiltrating tissue-resident memory CD8

Indexed as

astrocyteencephalitisFoxp3MCMVmicrogliareactive gliosisTregs

Identifiers

PMID26041050
PMCPMC4670295
OpenAlexW1870952375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.