Trial reportBrain imaging and behavior2016
Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women.
Trial report in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- A feature-based network analysis and fMRI meta-analysis reveal three distinct types of prosocial decisions.Social cognitive and affective neuroscience · 2021Pooled it
- The interaction of oxytocin and nicotine addiction on psychosocial stress: an fMRI study.Translational psychiatry · 2024Trial
- Neurobiobehavioral responses to virtual social rejection in females-exploring the influence of oxytocin.Social cognitive and affective neuroscience · 2021Trial
- Oxytocin and vasopressin modulation of prisoner's dilemma strategies.Journal of psychopharmacology (Oxford, England) · 2020Trial
- Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Vasopressin enhances human preemptive strike in both males and females.Scientific reports · 2019Trial
- Within vs. between-subject effects of intranasal oxytocin on the neural response to cooperative and non-cooperative social interactions.Psychoneuroendocrinology · 2017Trial
- Oxytocin biases men but not women to restore social connections with individuals who socially exclude them.Scientific reports · 2017Trial
- Plasma copeptin is coupled to resting-state frontoinsular-subgenual alpha dynamics in major depression with comorbid post-traumatic stress disorder.Frontiers in endocrinology · 2026Article
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Computer anthropomorphisation in a socio-economic dilemma.Behavior research methods · 2024Article
- Supportive care of female hormones in brain health: what and how?Frontiers in pharmacology · 2024Review
- Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Oxytocin and the social facilitation of placebo effects.Molecular psychiatry · 2022Review
- A Combined Administration of Testosterone and Arginine Vasopressin Affects Aggressive Behavior in Males.Brain sciences · 2021Article
- Review
- The role of oxytocin signaling in depression and suicidality in returning war veterans.Psychoneuroendocrinology · 2021Article
- Age and intranasal oxytocin effects on trust-related decisions after breach of trust: Behavioral and brain evidence.Psychology and aging · 2021Article
- The Biology of Vasopressin.Biomedicines · 2021Review
- Chronic oxytocin administration in older men modulates functional connectivity during animacy perception.Aging brain · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Anxiety disorders are characterized by hyperactivity in both the amygdala and the anterior insula. Interventions that normalize activity in these areas may therefore be effective in treating anxiety disorders. Recently, there has been significant interest in the potential use of oxytocin (OT), as well as vasopressin (AVP) antagonists, as treatments for anxiety disorders. In this double-blind, placebo-controlled, pharmaco- fMRI study, 153 men and 151 women were randomized to treatment with either 24 IU intranasal OT, 20 IU intranasal AVP, or placebo and imaged with fMRI as they played the iterated Prisoner's Dilemma game with same-sex human and computer partners. In men, OT attenuated the fMRI response to unreciprocated cooperation (CD), a negative social interaction, within the amygdala and anterior insula. This effect was specific to interactions with human partners. In contrast, among women, OT unexpectedly attenuated the amygdala and anterior insula response to unreciprocated cooperation from computer but not human partners. Among women, AVP did not significantly modulate the response to unreciprocated cooperation in either the amygdala or the anterior insula. However, among men, AVP attenuated the BOLD response to CD outcomes with human partners across a relatively large cluster including the amygdala and the anterior insula, which was contrary to expectations. Our results suggest that OT may decrease the stress of negative social interactions among men, whereas these effects were not found in women interacting with human partners. These findings support continued investigation into the possible efficacy of OT as a treatment for anxiety disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.