Evidence map›Paper›PMID 26040923›Full record

ReviewPsychological medicine2015

Behavioral and neurodevelopmental precursors to binge-type eating disorders: support for the role of negative valence systems.

A Vannucci, E E Nelson, D M Bongiorno, D S Pine, J A Yanovski, M Tanofsky-Kraff

Registry-linked trialAbstract readReview
In one paragraph

Review in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06387719 (Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06387719 unknown statusnot on this mapstarted 2023, after this paper: background citation

Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity: Early MRI Markers of Brain Reward and Inhibition Processing Dysfunction

Typeobservational_patient_registrySponsorFundació Sant Joan de DéuRan2023 to 2026Enrolled102ConditionsBinge-Eating Disorder, Obesity, Eating Disorders, BEDArmsMagnetic resonance imaging
3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.Journal of psychopharmacology (Oxford, England) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Benefits of Exercise in Multidisciplinary Treatment of Binge Eating Disorder in Adolescents with Obesity.International journal of environmental research and public health · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A VannucciDepartment of Medical and Clinical Psychology,Uniformed Services University of the Health Sciences,Bethesda,MD,USA.
E E NelsonSection on Development and Affective Neuroscience of the National Institute of Mental Health,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
D M BongiornoSection on Development and Affective Neuroscience of the National Institute of Mental Health,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
D S PineSection on Development and Affective Neuroscience of the National Institute of Mental Health,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
J A YanovskiSection on Growth and Obesity,Program in Developmental Endocrinology and Genetics,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
M Tanofsky-KraffDepartment of Medical and Clinical Psychology,Uniformed Services University of the Health Sciences,Bethesda,MD,USA.

Funding

Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Intramural NIH HHS Z99 HD999999Intramural NIH HHS Z99 MH999999Intramural NIH HHS ZIA HD000641PHS HHS 1ZIAHD000641
6 · The paper itself

Abstract

backgroundPediatric loss-of-control (LOC) eating is a robust behavioral precursor to binge-type eating disorders. Elucidating precursors to LOC eating and binge-type eating disorders may refine developmental risk models of eating disorders and inform interventions.

methodWe review evidence within constructs of the Negative Valence Systems (NVS) domain, as specified by the Research Domain Criteria framework. Based on published studies, we propose an integrated NVS model of binge-type eating-disorder risk.

resultsData implicate altered corticolimbic functioning, neuroendocrine dysregulation, and self-reported negative affect as possible risk factors. However, neuroimaging and physiological data in children and adolescents are sparse, and most prospective studies are limited to self-report measures.

conclusionsWe discuss a broad NVS framework for conceptualizing early risk for binge-type eating disorders. Future neural and behavioral research on the developmental trajectory of LOC and binge-type eating disorders is required.

Indexed as

AgingGene-Environment InteractionAdolescentBinge-Eating DisorderChildFeeding BehaviorHumansBinge eatingdevelopmenteating disordersloss of control eatingResearch Domain Criteria (RDoC)

Identifiers

PMID26040923
PMCPMC4589435

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.