ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Matrix metalloproteinase-12 expression is increased in cutaneous melanoma and associated with tumor aggressiveness.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
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- Comprehensive Analysis of Prognostic Value and Immune Infiltration of MMP12 in Esophageal Squamous Cell Carcinoma.Journal of oncology · 2022Article
- Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells.Histochemistry and cell biology · 2021Article
- Role of Biomarkers in the Integrated Management of Melanoma.Disease markers · 2021Review
- Identification of Chemical Profiles and Biological Properties ofAntioxidants (Basel, Switzerland) · 2020Article
- The prognostic values of matrix metalloproteinases in ovarian cancer.The Journal of international medical research · 2020Article
- TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness.Journal of experimental & clinical cancer research : CR · 2018Article
- Association Between Oxidative Stress and Melanoma Progression.Journal of medical biochemistry · 2018Article
- Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.Molecular carcinogenesis · 2018Article
- Article
- Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis.International journal of molecular sciences · 2016Review
- TET2 Negatively Regulates Nestin Expression in Human Melanoma.The American journal of pathology · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous melanoma is the most malignant form of skin cancer characterized by aggressive invasion. Matrix metalloproteinases play essential roles in tumor invasion due to their ECM degrading capacity. However, the clinical significance of matrix metalloproteinasis (MMP)-12 in human cutaneous melanoma has not been addressed yet. In the present study, we investigated MMP-12 expression level in 298 patients with cutaneous melanoma and 60 normal skin tissue specimens by immunohistochemistry assay. Appropriate statistical analysis was utilized to determine the association of MMP-12 with clinical features and prognosis of melanoma. Results showed that MMP-12 expression was increased in cutaneous melanoma compared with that in normal skin. It was also found that MMP-12 expression in melanoma was significantly associated with tumor invasion and metastasis. Univariate survival analysis indicated that patients with melanoma of high MMP-12 expression had unfavorable overall survival compared with those of low MMP-12 expression. Cox's proportional hazards analysis showed that MMP-12 expression was an independent prognostic marker of overall survival for patients with cutaneous melanoma. These results proved that MMP-12 expression was increased in cutaneous melanoma and associated with tumor progression. It also provided the first evidence that MMP-12 level could be an independent prognostic marker for patients with cutaneous melanoma.
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