ArticleJournal of the Royal Society, Interface2015
Microbuckling of fibrin provides a mechanism for cell mechanosensing.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.PLoS computational biology · 2025Article
- Direct detection of deformation modes on varying length scales in active biopolymer networks.bioRxiv : the preprint server for biology · 2025Article
- Compressive instabilities enable cell-induced extreme densification patterns in the fibrous extracellular matrix: Discrete model predictions.PLoS computational biology · 2024Article
- Unexpected softening of a fibrous matrix by contracting inclusions.Acta biomaterialia · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Mechanical Intercellular Communication via Matrix-Borne Cell Force Transmission During Vascular Network Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Nanocolloidal hydrogel mimics the structure and nonlinear mechanical properties of biological fibrous networks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Optimal mechanical interactions direct multicellular network formation on elastic substrates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Inference of long-range cell-cell force transmission from ECM remodeling fluctuations.Communications biology · 2023Article
- Hybrid cellular Potts and bead-spring modeling of cells in fibrous extracellular matrix.Biophysical journal · 2023Article
- Local response and emerging nonlinear elastic length scale in biopolymer matrices.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Micromechanical remodeling of the extracellular matrix by invading tumors: anisotropy and heterogeneity.Soft matter · 2022Article
- Review
- Effect of hyaluronic acid on microscale deformations of collagen gels.Journal of the mechanical behavior of biomedical materials · 2022Article
- Random Fiber Network Loaded by a Point Force.Journal of applied mechanics · 2022Article
- Force Transmission in Disordered Fibre Networks.Frontiers in cell and developmental biology · 2022Article
- Effect of matrix heterogeneity on cell mechanosensing.Soft matter · 2021Article
- Directional cues in the tumor microenvironment due to cell contraction against aligned collagen fibers.Acta biomaterialia · 2021Article
- Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells.Biomedicines · 2021Article
- Nonlinear Mechanical Properties of Prestressed Branched Fibrous Networks.Biophysical journal · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological cells sense and respond to mechanical forces, but how such a mechanosensing process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that propagate over a longer range than predicted by linear elasticity. Synthetic, linear elastic hydrogels used in many mechanotransduction studies fail to capture this effect. We develop a nonlinear microstructural finite-element model for a fibre network to simulate localized deformations induced by cells. The model captures measured cell-induced matrix displacements from experiments and identifies an important mechanism for long-range cell mechanosensing: loss of compression stiffness owing to microbuckling of individual fibres. We show evidence that cells sense each other through the formation of localized intercellular bands of tensile deformations caused by this mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.