ArticlePsychological medicine2015
Emotion recognition deficits as predictors of transition in individuals at clinical high risk for schizophrenia: a neurodevelopmental perspective.
Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis.Translational psychiatry · 2022Pooled it
- Pooled it
- Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine.Biological psychiatry · 2023Trial
- A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis.Translational psychiatry · 2020Trial
- Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort.Schizophrenia bulletin · 2026Article
- Jumping to conclusions bias in early psychosis: Relationships with symptom dimensions, neurocognition and social cognition.Schizophrenia research. Cognition · 2026Article
- Impairments in biological motion perception reflect affective disturbance in individuals at clinical high-risk for psychosis.Schizophrenia research. Cognition · 2026Article
- Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication.Research square · 2026Article
- Multisensory integration of affective faces and voices in psychosis proneness.Schizophrenia (Heidelberg, Germany) · 2025Article
- Relationship Between Illness Duration and Social Cognitive Abilities in Schizophrenia Spectrum Disorder.Psychiatry and clinical psychopharmacology · 2025Article
- Altered brain dynamics of facial emotion processing in schizophrenia: a combined EEG/fMRI study.Schizophrenia (Heidelberg, Germany) · 2025Article
- The Relationship between Clinical and Psychophysical Assessments of Visual Perceptual Disturbances in Individuals at Clinical High Risk for Psychosis: A Preliminary Study.Brain sciences · 2024Article
- Face and emotion recognition in individuals diagnosed with schizophrenia, ultra-high risk for psychosis, unaffected siblings, and healthy controls in a sample from Turkey.Schizophrenia research. Cognition · 2024Article
- The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia.Neuroscience and biobehavioral reviews · 2024Review
- Negative symptoms and social cognition as mediators of the relationship between neurocognition and functional outcome in schizophrenia.Frontiers in psychiatry · 2024Article
- The Less Things Change, the More They Remain the Same: Impaired Neural Plasticity as a Critical Target for Drug Development in Neuropsychiatry.Advances in neurobiology · 2024Review
- Age-associated alterations in thalamocortical structural connectivity in youths with a psychosis-spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2023Article
- Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.Journal of psychopathology and clinical science · 2023Article
- Vocal emotion perception in schizophrenia and its diagnostic significance.BMC psychiatry · 2023Article
- Augmentation of learning in schizophrenia by D-serine is related to auditory and frontally-generated biomarkers: A randomized, double-blind, placebo-controlled study.Research square · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSchizophrenia is characterized by profound and disabling deficits in the ability to recognize emotion in facial expression and tone of voice. Although these deficits are well documented in established schizophrenia using recently validated tasks, their predictive utility in at-risk populations has not been formally evaluated.
methodThe Penn Emotion Recognition and Discrimination tasks, and recently developed measures of auditory emotion recognition, were administered to 49 clinical high-risk subjects prospectively followed for 2 years for schizophrenia outcome, and 31 healthy controls, and a developmental cohort of 43 individuals aged 7-26 years. Deficit in emotion recognition in at-risk subjects was compared with deficit in established schizophrenia, and with normal neurocognitive growth curves from childhood to early adulthood.
resultsDeficits in emotion recognition significantly distinguished at-risk patients who transitioned to schizophrenia. By contrast, more general neurocognitive measures, such as attention vigilance or processing speed, were non-predictive. The best classification model for schizophrenia onset included both face emotion processing and negative symptoms, with accuracy of 96%, and area under the receiver-operating characteristic curve of 0.99. In a parallel developmental study, emotion recognition abilities were found to reach maturity prior to traditional age of risk for schizophrenia, suggesting they may serve as objective markers of early developmental insult.
conclusionsProfound deficits in emotion recognition exist in at-risk patients prior to schizophrenia onset. They may serve as an index of early developmental insult, and represent an effective target for early identification and remediation. Future studies investigating emotion recognition deficits at both mechanistic and predictive levels are strongly encouraged.
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