ArticleProceedings of the National Academy of Sciences of the United States of America2015
pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
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- Secondary Sites of the C-type Lectin-Like Fold.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Review
- Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis.Frontiers in immunology · 2023Article
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- Variegated Outcomes of T Cell Activation by Dendritic Cells in the Steady State.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- SYNBIP: synthetic binding proteins for research, diagnosis and therapy.Nucleic acids research · 2022Article
- A CD205-directed antibody drug conjugate - lymphoma precision oncology or sophisticated chemotherapy?Haematologica · 2020Article
- Review
- C-type lectins in immunity and homeostasis.Nature reviews. Immunology · 2018Review
- Tolerogenic interactions between CD8Blood · 2017Article
- Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.The EMBO journal · 2016Article
- Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4.Structure (London, England : 1993) · 2015Article
- Expression and crystallographic studies of the ligand-binding region of the human endocytic collagen receptor uPARAP.Acta crystallographica. Section F, Structural biology communications · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors. However, little is known about its structure and functional mechanism. Here we determine the structure of the human DEC205 ectodomain by cryoelectron microscopy. The structure shows that the 12 extracellular domains form a compact double ring-shaped conformation at acidic pH and become extended at basic pH. Biochemical data indicate that the pH-dependent conformational change of DEC205 is correlated with ligand binding and release. DEC205 only binds to apoptotic and necrotic cells at acidic pH, whereas live cells cannot be recognized by DEC205 at either acidic or basic conditions. These results suggest that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.