ArticleProceedings of the National Academy of Sciences of the United States of America2015
Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- Intra-species competition combats vancomycin-resistant enterococci.Gut microbes · 2026Article
- Deciphering the gastrointestinal carriage ofInfection and immunity · 2024Review
- Enterococcus faecalis: implications for host health.World journal of microbiology & biotechnology · 2024Review
- Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy.BMC microbiology · 2024Review
- An Overview of the Factors Involved in Biofilm Production by theInternational journal of molecular sciences · 2023Review
- Microbiota-mediated colonization resistance: mechanisms and regulation.Nature reviews. Microbiology · 2023Review
- A Tale of Two Pandemics: Antimicrobial Resistance Patterns ofAntibiotics (Basel, Switzerland) · 2023Article
- Pheromone Activity after Stimulation with Ampicillin in a Plasmid-FreeMicroorganisms · 2022Article
- Bavachin Suppresses Alpha-Hemolysin Expression and Protects Mice from Pneumonia Infection byJournal of microbiology and biotechnology · 2022Article
- Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A.Virulence · 2021Article
- Metabolism of Poly-β1,4-Journal of bacteriology · 2021Article
- Emerging Applications of Bacteriocins as Antimicrobials, Anticancer Drugs, and Modulators of The Gastrointestinal Microbiota.Polish journal of microbiology · 2021Review
- Multidrug-Resistant Bacteria in the Community: An Update.Infectious disease clinics of North America · 2020Review
- Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides-A Review.Pathogens (Basel, Switzerland) · 2020Review
- Article
- Spotlight on the Selected New Antimicrobial Innate Immune Peptides Discovered During 2015-2019.Current topics in medicinal chemistry · 2020Review
- Comparative genetics of Enterococcus faecalis intestinal tissue isolates before and after surgery in a rat model of colon anastomosis.PloS one · 2020Article
- Article
- Pathogenicity of Enterococci.Microbiology spectrum · 2019Review
- Colonization of the mammalian intestinal tract by enterococci.Current opinion in microbiology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Multidrug-resistant Enterococcus faecalis possess numerous mobile elements that encode virulence and antibiotic resistance traits as well as new metabolic pathways, often constituting over one-quarter of the genome. It was of interest to determine how this large accretion of mobile elements affects competitive growth in the gastrointestinal (GI) tract consortium. We unexpectedly observed that the prototype clinical isolate strain V583 was actively killed by GI tract flora, whereas commensal enterococci flourished. It was found that killing of V583 resulted from lethal cross-talk between accumulated mobile elements and that this cross-talk was induced by a heptapeptide pheromone produced by native E. faecalis present in the fecal consortium. These results highlight two important aspects of the evolution of multidrug-resistant enterococci: (i) the accretion of mobile elements in E. faecalis V583 renders it incompatible with commensal strains, and (ii) because of this incompatibility, multidrug-resistant strains sharing features found in V583 cannot coexist with commensal strains. The accumulation of mobile elements in hospital isolates of enterococci can include those that are inherently incompatible with native flora, highlighting the importance of maintaining commensal populations as means of preventing colonization and subsequent infection by multidrug-resistant strains.
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