ArticleClinics (Sao Paulo, Brazil)2015
The reduction of serum aminotransferase levels is proportional to the decline of the glomerular filtration rate in patients with chronic kidney disease.
Article in Clinics (Sao Paulo, Brazil), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Toxicological Profile of aJournal of toxicology · 2026Article
- Aspartate/alanine aminotransferase ratio and development of chronic kidney disease in non-diabetic men and women: a population-based longitudinal study in Kagawa, Japan.Clinical and experimental nephrology · 2025Article
- Chronic Oral D-Galactose Induces Oxidative Stress but Not Overt Organ Dysfunction in Male Wistar Rats.Current issues in molecular biology · 2025Article
- Construction and validation of a nomogram for detecting chronic kidney disease in patients with nonalcoholic fatty liver disease: Insights from the NHANES database.Clinics (Sao Paulo, Brazil) · 2025Article
- Effects of maternal overnutrition and metabolic challenge in adult life on the histological integrity of the liver and intestinal epithelium in rabbits.Frontiers in nutrition · 2025Article
- Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats.Toxics · 2024Article
- Clinical Evidence of the Relationship Between Alanine Aminotransferase and Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Evaluation of liver function biomarkers, blood pressure, and anthropometric parameters among chronic kidney disease patients: Laboratory-based cross-sectional study in Northwest Ethiopia.Metabolism open · 2023Article
- Associations of non-invasive indices of liver steatosis and fibrosis with progressive kidney impairment in adults with type 2 diabetes.Acta diabetologica · 2023Article
- Liver-function parameters are associated with incident hypertension in a large Taiwanese population follow-up study.Journal of human hypertension · 2023Article
- Can CBC Profile and Liver Function Test Predict Chronic Kidney Disease among a Normal Population?International journal of preventive medicine · 2023Article
- Mendelian randomization reveals causal effects of kidney function on various biochemical parameters.Communications biology · 2022Article
- Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway.Frontiers in pharmacology · 2022Article
- Cytomegalovirus infection after renal transplantation.Journal of medicine and life · 2022Article
- Simple metabolic markers associated with tophaceous gout.Clinical rheumatology · 2021Article
- Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases.Biomolecules · 2021Review
- Trace Element Levels in Serum Are Potentially Valuable Diagnostic Markers in Dogs.Animals : an open access journal from MDPI · 2020Article
- An Update on Population Pharmacokinetic Analyses of Vancomycin, Part I: In Adults.Clinical pharmacokinetics · 2020Review
- Experimental rat model for acute tubular injury induced by high water hardness and high water fluoride: efficacy of primary preventive intervention by distilled water administration.BMC nephrology · 2020Article
- A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study sought to determine the serum aminotransferase levels of patients with predialysis chronic kidney disease and establish their relationships with serum creatinine levels and glomerular filtration rate.
methodsPatients with chronic kidney disease were evaluated between September 2011 and May 2012. Aminotransferase and creatinine serum levels were measured using an automated kinetic method, and glomerular filtration rates were estimated using the Cockroft-Gault and Modification of Diet in Renal Disease formulas to classify patients into chronic kidney disease stages.
resultsExactly 142 patients were evaluated (mean age: 64±16 years). The mean creatinine serum level and glomerular filtration rate were 3.3±1.2 mg/dL and 29.1±13 mL/min/1.73 m2, respectively. Patients were distributed according to their chronic kidney disease stages as follows: 3 (2.1%) patients were Stage 2; 54 (38%) were Stage 3; 70 (49.3%) were Stage 4; and 15 (10.5%) were Stage 5. The mean aspartate aminotransferase and alanine aminotransferase serum levels showed a reduction in proportion to the increase in creatinine levels (p=0.001 and p=0.05, respectively) and the decrease in glomerular filtration rate (p=0.007 and p=0.028, respectively). Alanine aminotransferase and aspartate aminotransferase serum levels tended to be higher among patients classified as stage 2 or 3 compared with those classified as stage 4 or 5 (p=0.08 and p=0.06, respectively).
conclusionsThe aspartate aminotransferase and alanine aminotransferase serum levels of patients with predialysis chronic kidney disease decreased in proportion to the progression of the disease; they were negatively correlated with creatinine levels and directly correlated with glomerular filtration rate.
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