Evidence map›Paper›PMID 26039945›Full record

ArticleClinics (Sao Paulo, Brazil)2015

Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus.

Karina de Oliveira Peliçari, Mariana Postal, Nailú Angelica Sinicato, Fernando Augusto Peres, Paula Teixeira Fernandes, Roberto Marini, Lilian Tereza Lavras Costallat, Simone Appenzeller

Open access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Plasticity of CD4Journal of oncology · 2018
    Article
  8. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Karina de Oliveira PeliçariRheumatology Laboratory, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Mariana PostalRheumatology Laboratory, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Nailú Angelica SinicatoRheumatology Laboratory, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Fernando Augusto PeresRheumatology Laboratory, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Paula Teixeira FernandesDepartment of Sport Sciences, Faculty of Physical Education, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Roberto MariniPediatric Rheumatology Unit, Faculty of Medical Science, Department of Pediatrics, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Lilian Tereza Lavras CostallatRheumatology Unit, Faculty of Medical Science Department of Medicine, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Simone AppenzellerRheumatology Laboratory, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment.

methodsWe included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits.

resultsThe median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63).

conclusionIL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus.

Indexed as

AdolescentAdultAge of OnsetAnxietyBrazilCase-Control StudiesChildCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFamilyFemaleHumansInterleukin-17Lupus Erythematosus, SystemicMaleNephritisInterleukin-17

Identifiers

PMID26039945
PMCPMC4449477
OpenAlexW1960349388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.