ArticleScientific reports2015
Genetically assembled fluorescent biosensor for in situ detection of bio-synthesized alkanes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Directed evolution of hydrocarbon-producing enzymes.Biotechnology for biofuels and bioproducts · 2025Review
- Development of a whole-cell biosensor for ethylene oxide and ethylene.Microbial biotechnology · 2024Article
- Engineered l-Lactate Responding Promoter System Operating in Glucose-Rich and Anoxic Environments.ACS synthetic biology · 2021Article
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- Synthetic Biology Approaches to Hydrocarbon Biosensors: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- Article
- In vivo biosensors: mechanisms, development, and applications.Journal of industrial microbiology & biotechnology · 2018Article
- Production of alkanes from COBiotechnology for biofuels · 2018Article
- Biobased production of alkanes and alkenes through metabolic engineering of microorganisms.Journal of industrial microbiology & biotechnology · 2017Review
- Microbial synthesis of propane by engineering valine pathway and aldehyde-deformylating oxygenase.Biotechnology for biofuels · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Construction of highly efficient microbial cell factories producing drop-in biofuel alkanes is severely limited due to the lack of a fast detection method against alkanes. Here we first developed a sensitive fluorescent biosensor for rapid and in situ monitoring of intracellular alkane synthesis. Using GFP as reporter, the biosensor could actively respond to the intracellular alkane products, especially for the mid- and long-chain alkanes synthesized in the recombinant Escherichia coli and give a concentration-dependent fluorescence response. Our results also suggested the feasibility of developing high-throughput strategies basing on the alkane biosensor device in E. coli, and thus will greatly facilitate the application of directed evolution strategies to further improve the alkane-producing microbial cell factories.
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