ArticlePLoS biology2015
Mesoscopic patterns of neural activity support songbird cortical sequences.
Article in PLoS biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
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- A feedforward inhibitory premotor circuit for auditory-vocal interactions in zebra finches.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Miniature microscopes for manipulating and recording in vivo brain activity.Microscopy (Oxford, England) · 2021Article
- Local field potentials in a pre-motor region predict learned vocal sequences.PLoS computational biology · 2021Article
- Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes.Frontiers in neural circuits · 2021Review
- Manipulations of inhibition in cortical circuitry differentially affect spectral and temporal features of Bengalese finch song.Journal of neurophysiology · 2020Article
- Robust dynamical invariants in sequential neural activity.Scientific reports · 2019Article
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- Leveraging calcium imaging to illuminate circuit dysfunction in addiction.Alcohol (Fayetteville, N.Y.) · 2019Review
- Circuit Investigations With Open-Source Miniaturized Microscopes: Past, Present and Future.Frontiers in cellular neuroscience · 2019Review
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- Quantitative simulation of extracellular single unit recording from the surface of cortex.Journal of neural engineering · 2018Article
- Stable Sequential Activity Underlying the Maintenance of a Precisely Executed Skilled Behavior.Neuron · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Time-locked sequences of neural activity can be found throughout the vertebrate forebrain in various species and behavioral contexts. From "time cells" in the hippocampus of rodents to cortical activity controlling movement, temporal sequence generation is integral to many forms of learned behavior. However, the mechanisms underlying sequence generation are not well known. Here, we describe a spatial and temporal organization of the songbird premotor cortical microcircuit that supports sparse sequences of neural activity. Multi-channel electrophysiology and calcium imaging reveal that neural activity in premotor cortex is correlated with a length scale of 100 µm. Within this length scale, basal-ganglia-projecting excitatory neurons, on average, fire at a specific phase of a local 30 Hz network rhythm. These results show that premotor cortical activity is inhomogeneous in time and space, and that a mesoscopic dynamical pattern underlies the generation of the neural sequences controlling song.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.