Evidence map›Paper›PMID 26039869›Full record

ReviewBone2015

Non-coding RNAs: Epigenetic regulators of bone development and homeostasis.

Mohammad Q Hassan, Coralee E Tye, Gary S Stein, Jane B Lian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 103 citations in OpenAlex.

  1. Review
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  12. [Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Article
  13. Article
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  15. Article
  16. Role of long non-coding RNA H19 in the development of osteoporosis.Molecular medicine (Cambridge, Mass.) · 2021
    Review
  17. Role of m6A in osteoporosis, arthritis and osteosarcoma (Review).Experimental and therapeutic medicine · 2021
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mohammad Q HassanDepartment of Oral & Maxillofacial Surgery, School of Dentistry, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: hassank@uab.edu.
Coralee E TyeDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA. Electronic address: coralee.tye@uvm.edu.
Gary S SteinDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA. Electronic address: gary.stein@uvm.edu.
Jane B LianDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA. Electronic address: jane.lian@uvm.edu.
University of Vermont · USUniversity of Alabama at Birmingham · US

Funding

Synthesis of Osteocalcin in BoneR37DE012528 · NIDCR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B. · 2008 to 2017
$5.0M
NIDCR NIH HHS R37 DE012528
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) have evolved in eukaryotes as epigenetic regulators of gene expression. The most abundant regulatory ncRNAs are the 20-24 nt small microRNAs (miRNAs) and long non-coding RNAs (lncRNAs, <200 nt). Each class of ncRNAs operates through distinct mechanisms, but their pathways to regulating gene expression are interrelated in ways that are just being recognized. While the importance of lncRNAs in epigenetic control of transcription, developmental processes and human traits is emerging, the identity of lncRNAs in skeletal biology is scarcely known. However, since the first profiling studies of miRNA at stages during osteoblast and osteoclast differentiation, over 1100 publications related to bone biology and pathologies can be found, as well as many recent comprehensive reviews summarizing miRNA in skeletal cells. Delineating the activities and targets of specific miRNAs regulating differentiation of osteogenic and resorptive bone cells, coupled with in vivo gain- and loss-of-function studies, discovered unique mechanisms that support bone development and bone homeostasis in adults. We present here "guiding principles" for addressing biological control of bone tissue formation by ncRNAs. This review emphasizes recent advances in understanding regulation of the process of miRNA biogenesis that impact on osteogenic lineage commitment, transcription factors and signaling pathways. Also discussed are the approaches to be pursued for an understanding of the role of lncRNAs in bone and the challenges in addressing their multiple and complex functions. Based on new knowledge of epigenetic control of gene expression to be gained for ncRNA regulation of the skeleton, new directions for translating the miRNAs and lncRNAs into therapeutic targets for skeletal disorders are possible. This article is part of a Special Issue entitled Epigenetics and Bone.

Indexed as

Epigenesis, GeneticAdultAnimalsBone and BonesBone DevelopmentCell LineageHomeostasisHumansMicroRNAsModels, BiologicalRNA, UntranslatedSignal TransductionMicroRNAsRNA, UntranslatedLncRNAsMicroRNAmiRNA biogenesisOsteoblasts

Identifiers

PMID26039869
PMCPMC6095476
OpenAlexW609404933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.