Evidence map›Paper›PMID 26039492›Full record

ArticleNano letters2015

Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules.

Somin Eunice Lee, Qian Chen, Ramray Bhat, Shayne Petkiewicz, Jessica M Smith, Vivian E Ferry, Ana Luisa Correia, A Paul Alivisatos, Mina J Bissell

Abstract read
In one paragraph

Article in Nano letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. iSCAT Fluctuation Microscopy of Plasmon Rulers Assembled from 8 nm and 16 nm Gold Nanoparticles.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026
    Article
  2. Review
  3. Plasmonic Nanostructure Biosensors: A Review.Sensors (Basel, Switzerland) · 2023
    Review
  4. Review
  5. Article
  6. Article
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  9. Article
  10. Review
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  12. Review
  13. Article
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  15. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Somin Eunice Lee
Qian Chen
Ramray Bhat∇Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore, 560012, India.
Shayne Petkiewicz
Jessica M Smith
Vivian E Ferry
Ana Luisa Correia
A Paul Alivisatos
Mina J Bissell

Funding

TRANS-NETWORK PROJECTSU54CA143836 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIPHARDT, JAN T. · 2009 to 2014
$15.1M
Definition of the Microenvironment in Breast CancerR01CA064786 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BISSELL, MINA · 1995 to 2020
$6.1M
Definition of Microenvironment in Breast CancerR37CA064786 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BISSELL, MINA · 2009 to 2013
$2.0M
Nanoplasmonics-enabled Quantitative Spatiotemporal Activity Mapping in EngineeredF32EB013972 · NIBIB · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI LEE, SOMIN · 2011 to 2012
$103k
NCI NIH HHS CA064786NCI NIH HHS CA143836NCI NIH HHS R01 CA064786NCI NIH HHS R37 CA064786NCI NIH HHS U54 CA143836NIBIB NIH HHS F32 EB013972
6 · The paper itself

Abstract

Plasmon rulers, consisting of pairs of gold nanoparticles, allow single-molecule analysis without photobleaching or blinking; however, current plasmon rulers are irreversible, restricting detection to only single events. Here, we present a reversible plasmon ruler, comprised of coupled gold nanoparticles linked by a single aptamer, capable of binding individual secreted molecules with high specificity. We show that the binding of target secreted molecules to the reversible plasmon ruler is characterized by single-molecule sensitivity, high specificity, and reversibility. Such reversible plasmon rulers should enable dynamic and adaptive live-cell measurement of secreted single molecules in their local microenvironment.

Indexed as

AnimalsAptamers, NucleotideCell LineEpithelial CellsGoldHumansMammary Glands, HumanMatrix Metalloproteinase 3Metal NanoparticlesMiceNanotechnologyOptical ImagingSurface Plasmon ResonanceAptamers, NucleotideGoldMatrix Metalloproteinase 3gold nanoparticleimagingplasmonsecreted moleculesingle-molecule

Identifiers

PMID26039492
PMCPMC4545488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.