ArticleCell metabolism2015
Leptin keeps working, even in obesity.
Article in Cell metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is leptin resistance the cause or the consequence of diet-induced obesity?International journal of obesity (2005) · 2018Pooled it
- Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet-Induced Obese Rats.Molecular nutrition & food research · 2025Article
- An alternative neural basis underlying leptin resistance.Cell reports · 2025Article
- History and future of leptin: Discovery, regulation and signaling.Metabolism: clinical and experimental · 2024Review
- Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.Biomolecules · 2021Review
- Anti-obesity therapy with peripheral CB1 blockers: from promise to safe(?) practice.International journal of obesity (2005) · 2020Review
- Obesity as a Risk Factor for Alzheimer's Disease: Implication of Leptin and Glutamate.Frontiers in neuroscience · 2019Article
- Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit.Cell reports · 2018Article
- Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet.Frontiers in endocrinology · 2018Article
- Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus-Ventral Tegmental Area Neurocircuitry Depends on Energy State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Obesity Pathogenesis: An Endocrine Society Scientific Statement.Endocrine reviews · 2017Review
- Leptin signalling pathways in hypothalamic neurons.Cellular and molecular life sciences : CMLS · 2016Review
- The role of leptin in central nervous system diseases.Neuroreport · 2016Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling. In this issue, Ottaway et al. (2015) use leptin antagonists to reveal persistence (or even elevation) of endogenous leptin signaling and physiologic action in diet-induced obesity.
Indexed as
Identifiers
26039442What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.