Evidence map›Paper›PMID 26039424›Full record

ArticlePloS one2015

Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population.

Xiaoling Xu, Jiwen Wang, Shuang-Mei Zhu, Ming Yang, Yun Fang, An Zhao, Qian Song, Weimin Mao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Contribution of Genetic Polymorphisms in Human Health.International journal of environmental research and public health · 2023
    Review
  4. Article
  5. Distinct Prognostic Values of Alcohol Dehydrogenase Family Members for Non-Small Cell Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiaoling XuCancer Research Institute, Hangzhou, Zhejiang Province, China; Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Province, China; Department of Medical Oncology, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou City, China.
Jiwen WangCancer Research Institute, Hangzhou, Zhejiang Province, China; Thoracic Surgery Department, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
Shuang-Mei ZhuDepartment of Radio-Chemotherapy Oncology, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ming YangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Yun FangDepartment of Medical Oncology, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou City, China.
An ZhaoCancer Research Institute, Hangzhou, Zhejiang Province, China; Thoracic Surgery Department, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China; Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Province, China.
Qian SongDepartment of Clinical Laboratory, Zhejiang Cancer Hospital, 38 Guangji Road, Hangzhou City, China.
Weimin MaoCancer Research Institute, Hangzhou, Zhejiang Province, China; Thoracic Surgery Department, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China; Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Province, China.
Zhejiang Cancer Hospital · CNBeijing University of Chemical Technology · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal squamous cell carcinoma (ESCC) is very common in China and is also one of the most common cancers worldwide. The purpose of this study was to examine the associations between genetic variants of various cancer-related genes and the risk of ESCC.

methodsIn this study, we first examined the association between 18 potentially disruptive genetic variants of 17 genes, including alcohol dehydrogenase 4 (ADH4) and checkpoint kinase 2 (CHEK2), and ESCC risk in a Hangzhou population of 617 patients matched with 534 controls. Among the 18 single nucleotide polymorphisms (SNPs), two were validated in a Jinan population of 540 patients matched with 550 controls.

resultsSixteen SNPs in 15 genes, including CHEK2, did not have significantly different allele frequency distributions between ESCC patients and control subjects. A significantly increased risk of developing ESCC was revealed in subjects with the AA genotype of rs3805322 (ADH4) compared with those with the AG or GG genotype by unconditional univariate logistic regression analysis. Using a dominant model, the CC genotype of rs4822983 (CHEK2) had a marginally significant protective effect compared to the CT and TT genotypes. The association of ESCC risk with these two SNPs (rs3805322 and rs4822983) was further validated in a Jinan case-control set. Individuals with the ADH4 rs3805322 AA or AG genotype had ORs of 1.10 (95% CI = 0.81-1.49, P < 0.001) or 1.86 (95% CI = 1.33-2.59, P = 0.559), respectively, for developing ESCC compared with individuals with the GG genotype. CHEK2 rs4822983 CC carriers showed a marginally significantly decreased ESCC risk compared with those carrying the CT and TT genotypes in the validation set (95% CI = 0.61-1.01, P = 0.064). However, no evidence of interaction existed between the two SNPs and smoking or drinking in the Jinan case-control set.

conclusionsIn conclusion, this current study provides substantial evidence that genetic polymorphisms of rs3805322 in the ADH4 gene may be associated with an increased risk of developing ESCC in two Chinese Han populations. Future studies to address the biological function of this polymorphism in the development of ESCC are warranted.

Indexed as

Polymorphism, Single NucleotideAdultAgedAlcohol DehydrogenaseAsian PeopleCarcinoma, Squamous CellCheckpoint Kinase 2ChinaEsophageal NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm ProteinsRisk FactorsAlcohol Dehydrogenasealcohol dehydrogenase IVCheckpoint Kinase 2CHEK2 protein, humanNeoplasm Proteins

Identifiers

PMID26039424
PMCPMC4454665
OpenAlexW2202253510

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.