ArticlePloS one2015
No evidence for ape Plasmodium infections in humans in Gabon.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Epidemiology and diversity of Plasmodium species in Franceville and their implications for malaria control.Scientific reports · 2024Article
- Malaria Prevalence in Asymptomatic and Symptomatic Children Living in Rural, Semi-Urban and Urban Areas in Eastern Gabon.Acta parasitologica · 2024Article
- Genomic insights into Plasmodium vivax population structure and diversity in central Africa.Malaria journal · 2024Article
- The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs.Communications biology · 2022Article
- Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes.Nature communications · 2022Article
- Review
- Ape Origins of Human Malaria.Annual review of microbiology · 2020Review
- Attraction of mosquitoes to primate odours and implications for zoonotic Plasmodium transmission.Medical and veterinary entomology · 2020Article
- Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon.Emerging infectious diseases · 2020Article
- Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution.PLoS biology · 2018Article
- Investigating zoonotic infection barriers to ape Plasmodium parasites using faecal DNA analysis.International journal for parasitology · 2018Article
- Adaptive Evolution of RH5 in ApemBio · 2018Article
- Molecular interactions governing host-specificity of blood stage malaria parasites.Current opinion in microbiology · 2017Review
- Wild bonobos host geographically restricted malaria parasites including a putative new Laverania species.Nature communications · 2017Article
- Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination.Cold Spring Harbor perspectives in medicine · 2017Review
- Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing.Malaria journal · 2017Article
- Out of Africa: origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax.International journal for parasitology · 2017Review
- Wild African great apes as natural hosts of malaria parasites: current knowledge and research perspectives.Primate biology · 2017Review
- Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas.Genome biology and evolution · 2016Article
- Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African great apes are naturally infected by a multitude of Plasmodium species most of them recently discovered, among which several are closely related to human malaria agents. However, it is still unknown whether these animals can serve as source of infections for humans living in their vicinity. To evaluate this possibility, we analysed the nature of Plasmodium infections from a bank of 4281 human blood samples collected in 210 villages of Gabon, Central Africa. Among them, 2255 were detected positive to Plasmodium using molecular methods (Plasmodium Cytochrome b amplification). A high throughput sequencing technology (454 GS-FLX Titanium technology, Roche) was then used to identify the Plasmodium species present within each positive sample. Overall, we identified with confidence only three species infecting humans in Gabon: P. falciparum, P. malariae and P. ovale. None of the species known to infect non-human primates in Central Africa was found. Our study shows that ape Plasmodium parasites of the subgenus Laverania do not constitute a frequent source of infection for humans. It also suggests that some strong host genetic barriers must exist to prevent the cross species transmission of ape Plasmodium in a context of ever increasing contacts between humans and wildlife.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.